Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells.

Abstract	In this study, we investigated the expression and function of thymosinalpha1 (Thyalpha1) in human pancreatic cancer. We found that human pancreatic cancer cell lines Panc-1, Panc03.27, ASPC-1, and PL45 cells significantly over-expressed the mRNA of Thyalpha1 as compared to the normal human pancreatic ductal epithelium (HPDE) cells.. Thyalpha1 mRNA and protein levels were also over-expressed in clinical pancreatic adenocarcinoma specimens. In addition, synthetic Thyalpha1 significantly promoted Panc-1 cell proliferation and increased phosphorylation of ERK1/2 and JNK. Furthermore, Thyalpha1 increased the secretion of multiple cytokines including IL-10, IL-13, and IL-17 in Panc-1 cells. Thus, Thyalpha1 may have a new role in pancreatic cancer pathogenesis.
Authors	Min Li, Louis W Feurino, Fei Li, Hao Wang, Qihui Zhai, William E Fisher, Changyi Chen, Qizhi Yao
Journal	Cancer letters (Cancer Lett) Vol. 248 Issue 1 Pg. 58-67 (Apr 08 2007) ISSN: 0304-3835 [Print] Ireland
PMID	16828224 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	Cytokines Interleukin-13 Interleukin-17 RNA, Messenger Interleukin-10 Thymosin JNK Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases Thymalfasin
Topics	Cell Line, Tumor Cell Proliferation (drug effects) Cytokines (metabolism) Dose-Response Relationship, Drug Enzyme Activation (drug effects) Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Interleukin-10 (metabolism) Interleukin-13 (metabolism) Interleukin-17 (metabolism) JNK Mitogen-Activated Protein Kinases (metabolism) Mitogen-Activated Protein Kinase 1 (metabolism) Mitogen-Activated Protein Kinase 3 (metabolism) Mitogen-Activated Protein Kinases (metabolism) Pancreatic Neoplasms (genetics, metabolism, pathology) RNA, Messenger (genetics, metabolism) Reverse Transcriptase Polymerase Chain Reaction Th2 Cells (metabolism) Thymalfasin Thymosin (analogs & derivatives, genetics, metabolism, pharmacology)

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