Abstract | BACKGROUND: METHODS: RESULTS: Renal cortical messenger RNA levels of TNF-alpha increased significantly and were twice as high in diabetic rats than in nondiabetic control rats. Enalapril administration nearly completely abolished the increase in TNF-alpha messenger RNA expression to the level observed in control rats. UAE was significantly correlated with urinary levels of TNF-alpha (r=0.68, P<0.05) and with renal TNF-alpha expression (r=0.51, P<0.05). CONCLUSION: DN was associated with increased renal expression of TNF-alpha and UAE. Enalapril administration prevented this enhanced expression of TNF-alpha and decreased urinary cytokine excretion and albuminuria. These data provide a novel insight into the pathogenic mechanisms of DN, and support the hypothesis that inflammatory mechanisms may play a significant role in the development and progression of renal injury secondary to diabetes mellitus.
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Authors | Juan F Navarro, Francisco J Milena, Carmen Mora, Candelaria León, Felix Claverie, Carlos Flores, Javier García |
Journal | Kidney international. Supplement
(Kidney Int Suppl)
Issue 99
Pg. S98-102
(Dec 2005)
ISSN: 0098-6577 [Print] United States |
PMID | 16336586
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- RNA, Messenger
- Tumor Necrosis Factor-alpha
- Angiotensin II
- Enalapril
- Peptidyl-Dipeptidase A
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Topics |
- Albuminuria
(physiopathology)
- Angiotensin II
(physiology)
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Animals
- Diabetes Mellitus, Experimental
(physiopathology)
- Diabetic Neuropathies
(etiology, genetics, physiopathology)
- Enalapril
(pharmacology)
- Gene Expression Regulation
(drug effects)
- Kidney Cortex
(chemistry)
- Male
- Peptidyl-Dipeptidase A
(metabolism)
- RNA, Messenger
(analysis)
- Rats
- Rats, Sprague-Dawley
- Renin-Angiotensin System
(drug effects, physiology)
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Necrosis Factor-alpha
(genetics, physiology, urine)
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