Abstract | BACKGROUND AND AIMS OF THE STUDY: PATIENTS AND METHODS: RESULTS: The mean MIF concentration in lacrimal fluid collected from healthy control subjects was 0.69+/-0.2 ng/ml. The mean tear MIF levels were 17.87+/-6.3 ng/ml in moderate-to-severe atopic dermatitis (SCORAD> or =15, P=0.002), 0.93+/-0.08 ng/ml in mild atopic dermatitis (SCORAD<15), and 2.76+/-0.86 ng/ml in allergic conjunctivitis (P=0.008). CONCLUSIONS: A proinflammatory cytokine MIF level was elevated in tears as well as serum in cases of severe atopic dermatitis. These results suggest that MIF may play an important role in the induction or enhancement of ophthalmic features related to severe atopic dermatitis.
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Authors | Nobuyoshi Kitaichi, Tadamichi Shimizu, Ayumi Honda, Riichiro Abe, Kazuhiro Ohgami, Kenji Shiratori, Hiroshi Shimizu, Shigeaki Ohno |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 244
Issue 7
Pg. 825-8
(Jul 2006)
ISSN: 0721-832X [Print] Germany |
PMID | 16331484
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Macrophage Migration-Inhibitory Factors
|
Topics |
- Adolescent
- Adult
- Conjunctivitis, Allergic
(metabolism)
- Dermatitis, Atopic
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Lacrimal Apparatus
(metabolism)
- Macrophage Migration-Inhibitory Factors
(metabolism)
- Male
- Middle Aged
- Tears
(metabolism)
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