Abstract | OBJECTIVE: STUDY DESIGN: We measured plasma and tracheal aspirate (TA) levels of interleukin-8 (IL-8), epithelial neutrophil activating peptide (ENA-78), IL-10, and IL-18 in 84 neonates with suspected sepsis or NEC. Thirty-one infants had bacterial sepsis, 19 had NEC, and 34 infants with negative results on cultures had sepsis syndrome. RESULTS: Plasma IL-8 and IL-10 levels were significantly increased in infants with bacterial sepsis compared with those in infants with sepsis syndrome. Plasma IL-8, ENA-78, and IL-10 levels were elevated in infants with NEC compared with those in infants with sepsis syndrome. TA IL-8 and IL-10 levels were also increased in infants with bacterial sepsis; TA ENA-78, and IL-18 were not elevated in infants with sepsis or NEC when compared with infants with sepsis syndrome. Plasma and TA cytokine levels correlated with hematologic parameters. Plasma cytokine levels were higher in infants who did not survive than in infants who did survive. CONCLUSIONS:
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Authors | Mary Catherine Harris, Carl T D'Angio, Paul R Gallagher, David Kaufman, Jacquelyn Evans, Laurie Kilpatrick |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 147
Issue 4
Pg. 462-8
(Oct 2005)
ISSN: 0022-3476 [Print] United States |
PMID | 16227031
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- CXCL5 protein, human
- Chemokine CXCL5
- Chemokines, CXC
- Interleukins
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Topics |
- Bacterial Infections
(metabolism, mortality)
- Chemokine CXCL5
- Chemokines, CXC
(metabolism)
- Critical Illness
- Enterocolitis, Necrotizing
(metabolism, mortality)
- Humans
- Infant
- Infant, Newborn
- Interleukins
(metabolism)
- Leukocyte Count
- Platelet Count
- Sepsis
(metabolism, mortality)
- Systemic Inflammatory Response Syndrome
(metabolism, mortality)
- Trachea
(metabolism)
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