Abstract |
Low concentrations of selenium (Se) predict mortality and cardiovascular diseases in some populations. The effect of Se on in vivo indicators of oxidative stress and inflammation, two important features of atherosclerosis, in human populations is largely unexplored. This study investigated the longitudinal association between serum selenium (s-Se) and a golden standard indicator of oxidative stress in vivo (8-iso- prostaglandin F2alpha, a major F2-isoprostane), an indicator of cyclooxygenase (COX)-mediated inflammation ( prostaglandin F2alpha), high sensitive C-reactive protein ( hsCRP), interleukin-6 (IL-6) and serum amyloid A protein (SAA) in a follow-up study of 27 years. The s-Se was measured in 615 Swedish men at 50 years of age in a health investigation. The status of oxidative stress and inflammation was evaluated in a re-investigation 27 years later by quantification of urinary 8-iso-PGF2alpha and 15-keto-dihydro-PGF2alpha (a major metabolite of PGF2alpha) and serum hsCRP, SAA and IL-6. Men in the highest quartile of s-Se at age 50 had decreased levels of 8-iso-PGF2alpha compared to all lower quartiles and decreased levels of PGF2alpha compared to all lower quartiles at follow-up. These associations were independent of BMI, diabetes, hyperlipidemia, hypertension, smoking, alpha-tocopherol and beta-carotene at baseline. The s-Se was not associated with hsCRP, SAA or IL-6 at follow-up. In conclusion, high concentrations of s-Se predict reduced levels of oxidative stress and subclinical COX-mediated (but not cytokine-mediated) inflammation in a male population. The associations between Se, oxidative stress and inflammation, respectively, might be related to the proposed cardiovascular protective property of Se.
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Authors | Johanna Helmersson, Johan Arnlöv, Bengt Vessby, Anders Larsson, Georg Alfthan, Samar Basu |
Journal | Free radical research
(Free Radic Res)
Vol. 39
Issue 7
Pg. 763-70
(Jul 2005)
ISSN: 1071-5762 [Print] England |
PMID | 16036356
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Inflammation Mediators
- Interleukin-6
- Isoprostanes
- Serum Amyloid A Protein
- 15-keto-13,14-dihydroprostaglandin F2alpha
- 8-epi-prostaglandin F2alpha
- C-Reactive Protein
- Dinoprost
- Selenium
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Topics |
- Aged
- Biomarkers
(blood, urine)
- C-Reactive Protein
(metabolism)
- Cardiovascular Diseases
(blood, epidemiology, urine)
- Cohort Studies
- Diet
- Dinoprost
(analogs & derivatives, urine)
- Follow-Up Studies
- Humans
- Inflammation
(blood)
- Inflammation Mediators
(blood)
- Interleukin-6
(blood)
- Isoprostanes
(pharmacology)
- Longitudinal Studies
- Male
- Middle Aged
- Oxidative Stress
- Radioimmunoassay
- Selenium
(administration & dosage, blood)
- Serum Amyloid A Protein
(metabolism)
- Sweden
(epidemiology)
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