Crohn's disease is a chronic inflammatory bowel disorder with a relapsing and remitting course. Once remission is achieved, the main aim of the management of
Crohn's disease is maintenance of that remission. Significant advances have been made into understanding the aetiology and pathogenesis of
inflammatory bowel disease. With these advances in understanding come increasing numbers of new agents and
therapies, aimed both at active disease and the subsequent maintenance of remission in
Crohn's disease. Current therapeutic strategies in maintaining remission in
Crohn's disease include 5-aminosalicylates (e.g.
sulfasalazine,
mesalazine), thiopurines (e.g.
azathioprine,
6-mercaptopurine [
mercaptopurine]),
methotrexate and
infliximab. The 5-aminosalicylates appear to have efficacy limited to either surgically induced remission and/or limited small bowel
Crohn's disease. The
immunomodulators now have an established role in Crohn's maintenance.
Azathioprine and
6-mercaptopurine are effective in chronic active disease and
corticosteroid-dependent
Crohn's disease.
Methotrexate has similar indications, although it appears to be an alternative in patients who are intolerant of, or resistant to, the thiopurines. The most recent breakthrough has been in the field of
biological therapy for maintenance of remission in
Crohn's disease. Treatment of patients with the anti-tumour
necrosis factor (
TNF)-alpha antibody
infliximab has been shown already to be effective in inducing remission. Recent studies have now confirmed a role for
infliximab in delaying relapse and maintaining remission in patients responsive to
infliximab induction
therapy. However, results with soluble
TNF alpha receptors have been disappointing. A number of other
biological and nonbiological agents have shown potential, though trials of the 'newer'
biological agents have thus far been disappointing, in the maintenance of remission in
Crohn's disease. The evidence for theses agents is currently limited, in many cases to treating active disease; however, these data are discussed in this article in order to provide an overview of future potential
therapies. The aim of this review is to provide clinicians with an insight into current and emerging therapeutic agents for the maintenance of remission of
Crohn's disease.