Abstract |
To investigate if severe malarial anemia is associated with specific cytokine overproduction, we evaluated serum levels of soluble Fas ligand (sFasL), tumor necrosis factor ( TNF-alpha) and interleukin-10 (IL-10) from three groups of young children with Plasmodium falciparum infection (asymptomatic cases, uncomplicated malaria cases and severe malarial anemia cases), in a hyperendemic area of Gabon. In uncomplicated cases, only TNF levels were significantly (p < 0.001) increased in comparison to asymptomatic cases with P. falciparum infection. High levels of sFasL, TNF-alpha and IL-10 were associated with low hemoglobin concentrations, sFasL levels were significantly higher in children with severe malarial anemia (p < 0.001) as compared to both other groups. The parasite density was positively correlated with IL-10, TNF-alpha and sFasL levels. TNF-alpha and sFasL, but not IL-10 or parasitemia, were independent predictors of hemoglobin concentrations. These results suggest that, in malaria, a specific dysregulation of the cytokine balance may lead to complications such as severe anemia.
|
Authors | Saadou Issifou, Elie Mavoungou, Steffen Borrmann, Marielle K Bouyou-Akotet, Pierre-Blaise Matsiegui, Peter G Kremsner, Francine Ntoumi |
Journal | European cytokine network
(Eur Cytokine Netw)
2003 Oct-Dec
Vol. 14
Issue 4
Pg. 238-41
ISSN: 1148-5493 [Print] France |
PMID | 14715416
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright John Libbey Eurotext 2003. |
Chemical References |
- FASLG protein, human
- Fas Ligand Protein
- Membrane Glycoproteins
- Tumor Necrosis Factor-alpha
- Interleukin-10
|
Topics |
- Acute Disease
- Anemia
(etiology, immunology, metabolism)
- Animals
- Child
- Child, Preschool
- Fas Ligand Protein
- Female
- Gabon
- Humans
- Infant
- Inflammation
(metabolism)
- Interleukin-10
(blood)
- Malaria, Falciparum
(immunology, metabolism)
- Male
- Membrane Glycoproteins
(blood)
- Plasmodium falciparum
(immunology)
- Tumor Necrosis Factor-alpha
(metabolism)
|