Abstract |
Febrile ulceronecrotic Mucha- Habermann's disease is an unusual severe form of pityriasis lichenoides et varioliformis acuta characterized by abrupt onset of ulceronecrotic eruption associated with a high fever and systemic symptoms. To our knowledge, 19 cases of this disease have been reported in the literature, and 4 of them were fatal. We report the case of a 12-year-old boy with this disorder who had abdominal pain, hypoproteinemia, and anemia. Although these associated symptoms are considered life-threatening factors according to reported cases, our patient was successfully treated with methylprednisolone semipulse and subsequent methotrexate therapies. From a review of the literature and the present case, we propose that when patients have these systemic symptoms, therapeutic choices include methotrexate, high-dose corticosteroids, and 4,4-diamino-diphenyl-sulfone, which may depress early development of this disease.
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Authors | Natsuho Ito, Akihiro Ohshima, Hideo Hashizume, Masahiro Takigawa, Yoshiki Tokura |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 49
Issue 6
Pg. 1142-8
(Dec 2003)
ISSN: 0190-9622 [Print] United States |
PMID | 14639403
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Methylprednisolone
- Methotrexate
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Topics |
- Child
- Fever
- Humans
- Male
- Methotrexate
(administration & dosage)
- Methylprednisolone
(administration & dosage)
- Pityriasis Lichenoides
(drug therapy, pathology)
- Pulse Therapy, Drug
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