Anti-inflammatory activity and effect on gastric acid secretion of dehydroleucodine isolated from Artemisia douglasiana.

Abstract

The effect of Dehydroleucodine (DhL) on gastric acid secretion in rats was investigated at a dose of 40 mg/kg, while its anti-inflammatory effect was investigated in two experimental models: arthritis induced by Freund's adjuvant carrageenan- and cotton pellet-induced granuloma. DhL did not inhibit gastric acid secretion, suggesting that its anti-ulcerogenic effect can be attributed to its action on the mucosa defense factors. On the other hand, DhL inhibited both chronic and acute adjuvant carrageenan-induced inflammation phases, being most effective in the chronic phase. In the granuloma test, DhL also inhibited inflammation. It is suggested that the anti-inflammatory activity of DhL may be attributed to interference with multiple targets on the level of transcription factors, such as NF-kappaB, and cytokines.

• Authors: T Guardia, A O Juarez, E Guerreiro, J A Guzmán, L Pelzer
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 88 Issue 2-3 Pg. 195-8 (Oct 2003) ISSN: 0378-8741 [Print] Ireland
• PMID: 12963142 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Lactones
• Plant Extracts
• Sesquiterpenes
• dehydroleucodine

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (isolation & purification, pharmacology)
• Artemisia (chemistry)
• Disease Models, Animal
• Female
• Gastric Acid (metabolism)
• Inflammation (chemically induced, drug therapy)
• Lactones (isolation & purification, pharmacology)
• Male
• Plant Components, Aerial (chemistry)
• Plant Extracts (pharmacology)
• Rats
• Rats, Wistar
• Sesquiterpenes (isolation & purification, pharmacology)