IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26.

Abstract

It has been reported that the CD4+ T cell is a very important source of interleukin 10 (IL-10), while CD8+ cells produce low amounts. IL-10 exerts several immune stimulating, as well as inhibitory effects. There are at least five novel human IL-10 family-related molecules: IL-19, IL-20, IL-22, IL-24, and IL-26. Activated T cells produce IL-19, IL-22 and IL-26, while IL-24 is produced by activated monocytes and T-cells. IL-20 induces cheratin proliferation and Stat-3 signal transduction pathway, while IL-22 induces acute-phase production by hepatocytes and neonatal lethality with skin abnormalities reminiscent of psoriasic lesions in humans. In addition, IL-22 mediates inflammation and binds class II cytokine receptor heterodimers IL-22 RA1/CRF2-4. This cytokine is also involved in immuno-regulatory responses. IL-26 (AK155) is a novel cytokine generated by memory cells and is involved in the transformed phenotype of human T cells after infection by herpes virus. All these new IL-10 subfamily member cytokines are strongly involved in immune regulation and inflammatory responses.

• Authors: P Conti, D Kempuraj, S Frydas, K Kandere, W Boucher, R Letourneau, B Madhappan, K Sagimoto, S Christodoulou, T C Theoharides
• Journal: Immunology letters (Immunol Lett) Vol. 88 Issue 3 Pg. 171-4 (Sep 08 2003) ISSN: 0165-2478 [Print] Netherlands
• PMID: 12941475 (Publication Type: Journal Article, Review)

Chemical References

• Interleukins
• Receptors, Cytokine
• Interleukin-10

Topics

• Animals
• Humans
• Immunologic Memory
• Interleukin-10 (genetics, immunology, metabolism)
• Interleukins (genetics, immunology, metabolism)
• Receptors, Cytokine (immunology)
• T-Lymphocytes (immunology)