Abstract | OBJECTIVE: DESIGN: Retrospective study. SETTING: Medical and surgical wards or intensive care units of two university hospitals. PATIENTS: INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We assessed circulating levels of nucleosomes, specific markers released by cells during the later stages of apoptosis, with a previously described enzyme-linked immunosorbent assay in these 69 patients with fever, systemic inflammatory response syndrome, severe sepsis, or septic shock. Severity of multiple organ dysfunction syndrome was assessed with sepsis scores, and clinical and laboratory variables. Elevated nucleosome levels were found in 64%, 60%, 94%, and 100% of patients with fever, systemic inflammatory response syndrome, severe sepsis, or septic shock, respectively. These levels were significantly higher in patients with septic shock as compared with patients with severe sepsis, systemic inflammatory response syndrome, or fever, and in nonsurvivors as compared with survivors. In patients with advanced multiple organ dysfunction syndrome, nucleosome levels correlated with cytokine plasma levels as well as with variables predictive for outcome. CONCLUSIONS:
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Authors | Sacha Zeerleder, Bas Zwart, Walter A Wuillemin, Lucien A Aarden, A B Johan Groeneveld, Christoph Caliezi, Annemarie E M van Nieuwenhuijze, Gerard J van Mierlo, Anke J M Eerenberg, Bernhard Lämmle, C Erik Hack |
Journal | Critical care medicine
(Crit Care Med)
Vol. 31
Issue 7
Pg. 1947-51
(Jul 2003)
ISSN: 0090-3493 [Print] United States |
PMID | 12847387
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Apoptosis
(physiology)
- Biomarkers
(blood)
- Enzyme-Linked Immunosorbent Assay
- Female
- Hospital Mortality
- Humans
- Intensive Care Units
- Male
- Middle Aged
- Multiple Organ Failure
(blood, diagnosis, mortality)
- Nucleosomes
(metabolism)
- Predictive Value of Tests
- Prognosis
- Shock, Septic
(blood, diagnosis, mortality)
- Survival Rate
- Systemic Inflammatory Response Syndrome
(blood, diagnosis, mortality)
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