Abstract | BACKGROUND: PATIENTS AND METHODS: Over a 4-year period, 985 women undergoing curative surgery for breast cancer (T1-3 N0-2 M0, stage I-IIIA, UICC) from nine hospitals were stratified with respect to axillary node involvement (node positive versus node negative) and randomized to receive either FAC (500/50/500/m(2)) every 3 weeks for six cycles or CMF (600/60/600/m(2)) every 3 weeks for six cycles. RESULTS: The relative dose intensities of FAC and CMF were 87% and 85% of planned doses, respectively. Unadjusted data indicated a non-significant trend towards better results with FAC. In the prospectively formed subset of node-negative patients, disease-free survival and overall survival were statistically superior in the FAC treatment arm (P = 0.041 and 0.034, respectively), but this advantage was not seen in the subset of node-positive patients, probably because of a difference in the percentage of patients with four or more positive nodes. Adjusting data for size of treatment effect and potential interactions (number of positive nodes, tumor size, treatment center), the overall relative risk (RR) of disease recurrence and death were significantly lower with FAC treatment (RR 1.2, P = 0.03, and RR 1.3, P = 0.05, respectively). This result was mainly due to the difference observed in the node-negative patient population. Toxicity was mild: FAC induced more alopecia, emesis, mucositis and cardiotoxicity; this last was of clinical concern, but was infrequent and manageable. CMF induced more conjunctivitis and weight gain. There were no toxic deaths. CONCLUSIONS:
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Authors | M Martin, A Villar, A Sole-Calvo, R Gonzalez, B Massuti, J Lizon, C Camps, A Carrato, A Casado, M T Candel, J Albanell, J Aranda, B Munarriz, J Campbell, E Diaz-Rubio, GEICAM Group (Spanish Breast Cancer Research Group), Spain |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 14
Issue 6
Pg. 833-42
(Jun 2003)
ISSN: 0923-7534 [Print] England |
PMID | 12796019
(Publication Type: Clinical Trial, Clinical Trial, Phase III, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Review)
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Chemical References |
- Doxorubicin
- Cyclophosphamide
- Fluorouracil
- Methotrexate
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Topics |
- Adolescent
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Breast Neoplasms
(drug therapy, mortality, surgery)
- Chemotherapy, Adjuvant
- Cyclophosphamide
(adverse effects, therapeutic use)
- Disease-Free Survival
- Dose-Response Relationship, Drug
- Doxorubicin
(adverse effects, therapeutic use)
- Female
- Fluorouracil
(adverse effects, therapeutic use)
- Humans
- Infusions, Intravenous
- Lymphatic Metastasis
- Methotrexate
(adverse effects, therapeutic use)
- Middle Aged
- Neoplasm Staging
- Neoplasms, Hormone-Dependent
(drug therapy, mortality, surgery)
- Prospective Studies
- Survival Rate
- Treatment Outcome
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