Effects of glossopharyngeal nerve transection on central and peripheral cytokines and serum corticosterone induced by localized inflammation.

Abstract	Bilateral transection of the glossopharyngeal nerves (GLOx) disrupts the immune-to-brain communication from the posterior oral cavity. The current report tested whether this effect is due to the afferent (sensory) or efferent (parasympathetic motor) components of the nerve. Injection of lipopolysaccharide (LPS) into the soft palate (ISP) of GLOx or sham-operated (SHAM) rats increased the circulating levels of interleukin-1beta (IL-1beta), interleukin-1 receptor antagonist (IL-1ra) and corticosterone (CORT), as well the hypothalamic content of IL-1beta; no difference in circulating levels and hypothalamic content was found between GLOx and SHAM at 2 and 4.5 h after LPS injection. These results indicate that glossopharyngeal neural efferents do not mediate the effects of GLOx on the immune-to-brain communication.
Authors	Horacio E Romeo, Delia L Tio, Anna N Taylor
Journal	Journal of neuroimmunology (J Neuroimmunol) Vol. 136 Issue 1-2 Pg. 104-11 (Mar 2003) ISSN: 0165-5728 [Print] Netherlands
PMID	12620648 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References	Cytokines Interleukin 1 Receptor Antagonist Protein Interleukin-1 Lipopolysaccharides Sialoglycoproteins Corticosterone
Topics	Afferent Pathways (immunology, injuries, surgery) Animals Corticosterone (blood, immunology, metabolism) Cytokines (blood, immunology, metabolism) Disease Models, Animal Glossopharyngeal Nerve (immunology, surgery) Glossopharyngeal Nerve Injuries Hypothalamus (immunology, metabolism) Inflammation (blood, immunology, physiopathology) Interleukin 1 Receptor Antagonist Protein Interleukin-1 (blood, metabolism) Lipopolysaccharides Male Mouth (immunology, innervation, physiopathology) Neuroimmunomodulation (immunology) Palate, Soft (immunology, innervation, physiopathology) Rats Rats, Sprague-Dawley Sialoglycoproteins (blood, metabolism)

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