[A case of advanced esophageal cancer with multiple lymph node metastases successfully treated with induction chemotherapy consisting of nedaplatin and 5-FU followed by chemoradiotherapy].

Abstract

A 61-year-old male patient had esophageal carcinoma with multiple mediastinal and right supraclavicular lymph node metastases. Chemotherapy consisting of infusion of nedaplatin and continuous infusion of 5-fluorouracil was performed. After three courses of the chemotherapy, the patient was treated with a combination of cisplatin and 5-FU and radiotherapy. However, only radiotherapy was performed after 18 Gy because of grade 3 leukocytonenia during the chemoradiotherapy. The patient achieved a partial response (nearly complete response) for 9 months after the initiation of the treatment. In conclusion, chemotherapy with NDP and 5-FU followed by chemoradiotherapy is effective and safe for patients with esophageal carcinoma with multiple lymph node metastases.

• Authors: Tomonari Sasaki, Katsumasa Nakamura, Takashi Toba, Masahiko Kimura, Saijo Ohga, Yusuke Urashima, Hiromi Terashima, Kouji Masuda
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 29 Issue 8 Pg. 1417-20 (Aug 2002) ISSN: 0385-0684 [Print] Japan
• PMID: 12214470 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Organoplatinum Compounds
• nedaplatin
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, radiotherapy, secondary)
• Drug Administration Schedule
• Esophageal Neoplasms (drug therapy, pathology, radiotherapy)
• Fluorouracil (administration & dosage)
• Humans
• Lymphatic Metastasis
• Male
• Middle Aged
• Organoplatinum Compounds (administration & dosage)
• Remission Induction