Abstract | BACKGROUND: The molecular basis of lipodystrophy, a syndrome associated with HIV antiretroviral (ARV) therapy, remains unknown. OBJECTIVES: To examine whether ARV therapy might inhibit the expression of CD36, which is known to play an important role in fatty acid and glucose metabolism, and if this might contribute to the metabolic alterations associated with lipodystrophy. DESIGN: The effects of ARV therapy on CD36 levels was examined in vivo in a prospective cohort of individuals treated with ARV therapy and in vitro in assays of human cell lines exposed to ARV drugs. METHODS: RESULTS: Three of four healthy controls (one withdrew because of adverse effects) and 6 of 10 HIV-1-infected individuals had a 50 to > 90% decrease in monocyte CD36 levels after 7 days of therapy. One of ten HIV-infected subjects had a 30% decrease, and the remaining individuals had no change or an increase in CD36 levels. CD36 levels decreased significantly in human cell lines treated with ritonavir but not in those treated with zidovudine. CONCLUSIONS:
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Authors | Lena Serghides, Salima Nathoo, Sharon Walmsley, Kevin C Kain |
Journal | AIDS (London, England)
(AIDS)
Vol. 16
Issue 3
Pg. 353-8
(Feb 15 2002)
ISSN: 0269-9370 [Print] England |
PMID | 11834946
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-HIV Agents
- CD36 Antigens
- Zidovudine
- Ritonavir
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Topics |
- Anti-HIV Agents
(adverse effects)
- Antiretroviral Therapy, Highly Active
(adverse effects)
- CD36 Antigens
(blood, metabolism)
- Cell Line
- Cohort Studies
- HIV Infections
(drug therapy, immunology)
- HIV-1
- Humans
- In Vitro Techniques
- Insulin Resistance
- Lipodystrophy
(chemically induced)
- Monocytes
(drug effects, immunology)
- Prospective Studies
- Ritonavir
(adverse effects)
- Zidovudine
(adverse effects)
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