Local injection of anti-cancer drugs bound to carbon particles for early gastric cancer--a pilot study.

Abstract

BACKGROUND/AIMS:

A new dosage formulation consisting of an anti-cancer drug bound to activated carbon particles was developed for a local injection against early gastric cancer so that the dosage formulation yields chemotherapeutic effects selectively to the lymph node metastases as well as to the primary lesion.

METHODOLOGY:

As a pilot study, the new dosage formulation, total of 50-200 mg of methotrexate only or total of 200 mg of methotrexate plus 8 mg of mitomycin C, was injected into the primary lesions and the adjacent gastric wall of 8 patients with early gastric cancer, guided by a gastrofiberscope before gastrectomy. The surgically resected specimens were examined histologically for the therapeutic effects on the primary lesion and its nodal metastasis.

RESULTS:

The therapeutic effects were seen in 2 of 4 lymph node metastases (50%) and 5 of 8 of the primary lesions (63%), as confirmed histologically with degeneration and/or necrosis.

CONCLUSIONS:

Preoperative local injection of the new dosage formulation will be useful to give chemotherapeutic effects on the potential metastases in the regional nodes as well as to the primary lesion.

• Authors: A Hagiwara, T Torii, K Sawai, C Sakakura, M Shirasu, M Ohgaki, T Imanishi, J Yamasaki, T Takahashi
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2000 Mar-Apr Vol. 47 Issue 32 Pg. 575-8 ISSN: 0172-6390 [Print] Greece
• PMID: 10791242 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Charcoal
• Mitomycin
• Methotrexate

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Charcoal
• Combined Modality Therapy
• Female
• Gastrectomy
• Humans
• Injections, Intralesional
• Lymph Node Excision
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Male
• Methotrexate (administration & dosage, adverse effects)
• Middle Aged
• Mitomycin (administration & dosage, adverse effects)
• Neoadjuvant Therapy
• Pilot Projects
• Stomach (pathology)
• Stomach Neoplasms (drug therapy, pathology, surgery)