Hematological recovery and peripheral blood progenitor cell mobilization after induction chemotherapy and GM-CSF plus G-CSF in breast cancer.

Abstract

In order to determine the effect of GM-CSF plus G-CSF in combination in breast cancer patients receiving an effective induction regimen, we compared hematological recovery and peripheral blood progenitor cell (PBPC) mobilization according to colony-stimulating factor (CSF) support. Forty-three breast cancer patients were treated by TNCF (THP-doxorubicin, vinorelbine, cyclophosphamide, fluorouracil, D1 to D4) with CSF support: 11 patients received GM-CSF (D5 to D14); 16 patients G-CSF (D5 to D14) and 16 patients GM-CSF (D5-D14) plus G-CSF (D10-D14). Between two subsequent cycles, progenitor cells were assessed daily, from D13 to D17. The WBC count was similar for patients receiving G-CSF alone or GM-CSF plus G-CSF, but significantly greater than that of patients receiving GM-CSF alone (P<0.001). The GM-CSF plus G-CSF combination led to better PBPC mobilization, with significantly different kinetics (P<0.001) and optimal mean values of CFU-GM, CD34+ cells and cells in cycle, at D15 compared to those obtained with G-CSF or GM-CSF alone. The significantly greater PBPC mobilization obtained with a CSF combination by D15 could be of value for PBPC collection and therapeutic reinjection after high-dose chemotherapies.

• Authors: S Charrier, P Chollet, J O Bay, H Curé, F Kwiatkowski, G Portefaix, Y Communal, G Bétail, R Plagne, J Chassagne
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 25 Issue 7 Pg. 705-10 (Apr 2000) ISSN: 0268-3369 [Print] England
• PMID: 10745254 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD
• Antigens, CD34
• Recombinant Proteins
• Granulocyte Colony-Stimulating Factor
• Vinblastine
• Doxorubicin
• Granulocyte-Macrophage Colony-Stimulating Factor
• Cyclophosphamide
• Fluorouracil

Topics

• Adult
• Aged
• Antigens, CD (blood)
• Antigens, CD34 (blood)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Breast Neoplasms (blood, drug therapy, immunology, therapy)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Female
• Fluorouracil (administration & dosage)
• Granulocyte Colony-Stimulating Factor (therapeutic use)
• Granulocyte-Macrophage Colony-Stimulating Factor (therapeutic use)
• Hematopoietic Stem Cell Mobilization
• Humans
• Leukocyte Count
• Leukocytes, Mononuclear (immunology)
• Middle Aged
• Recombinant Proteins
• Remission Induction
• Vinblastine (administration & dosage, analogs & derivatives)