Abstract | BACKGROUND: OBJECTIVES: METHODS: RESULTS: Specific IgG antibodies that recognize MDI-HSA conjugates were detected in all but 1 of the MDI-exposed workers and could not be found in TDI-exposed and HDI-exposed workers. The levels of specific IgG antibodies were more elevated when tested against the HSA conjugates formed with polymeric MDI compared with the HSA conjugates formed with monomeric MDI. CONCLUSION: This study shows that specific IgG antibodies to MDI appear to be specific for MDI without cross-reactivity with TDI and HDI and higher by use of polymeric rather than monomeric MDI-HSA test antigens.
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Authors | D J Aul, A Bhaumik, A L Kennedy, W E Brown, J Lesage, J L Malo |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 103
Issue 5 Pt 1
Pg. 749-55
(May 1999)
ISSN: 0091-6749 [Print] United States |
PMID | 10329805
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Allergens
- Immunoglobulin G
- Isocyanates
- Toluene 2,4-Diisocyanate
- 4,4'-diphenylmethane diisocyanate
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Topics |
- Adult
- Allergens
(immunology)
- Antibody Specificity
- Asthma
(immunology)
- Cross Reactions
- Female
- Forced Expiratory Volume
- Humans
- Immunoglobulin G
(immunology)
- Isocyanates
(immunology)
- Male
- Middle Aged
- Respiratory Hypersensitivity
(immunology)
- Toluene 2,4-Diisocyanate
(adverse effects)
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