Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx.

Abstract

We describe 5 patients with severe pompholyx who did not respond to conventional therapy or who had debilitating side effects from corticosteroids. Low-dose methotrexate was added to their treatment regimens and led to significant improvement or clearing with a favorable side-effect profile. In all 5 patients the need for oral corticosteroid therapy was substantially decreased or eliminated, thus decreasing potential corticosteroid-induced morbidity. In this uncontrolled series of patients with recalcitrant palmoplantar pompholyx, methotrexate was an effective treatment and acted as a steroid-sparing agent.

• Authors: C A Egan, T M Rallis, K P Meadows, G G Krueger
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 40 Issue 4 Pg. 612-4 (Apr 1999) ISSN: 0190-9622 [Print] United States
• PMID: 10188683 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Steroids
• Methotrexate

Topics

• Administration, Oral
• Adult
• Anti-Inflammatory Agents (administration & dosage, adverse effects)
• Dose-Response Relationship, Drug
• Drug Therapy, Combination
• Eczema, Dyshidrotic (diagnosis, drug therapy)
• Female
• Humans
• Male
• Methotrexate (administration & dosage)
• Middle Aged
• Steroids