Cytochrome P-450 CYP2A6

A cytochrome P450 enzyme that has specificity for the 7-hydroxylation of coumarin.

Also Known As:

Coumarin 7-Hydroxylase; Coumarin Hydroxylase; Cytochrome P450 CYP2A6; Cytochrome P450, Family 2, Subfamily A, Polypeptide 6; Coumarin 7 Hydroxylase; Cytochrome P 450 CYP 2A3; Cytochrome P 450 CYP2A6; P450 CYP2A6, Cytochrome; Cytochrome P-450 CYP-2A3

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cao, Yuzhen: 1 article (01/2013)
2.	Guo, Guifang: 1 article (01/2013)
3.	Li, Rui: 1 article (01/2013)
4.	Liu, Fangping: 1 article (01/2013)
5.	Wang, Yuanyuan: 1 article (01/2013)
6.	Zhang, Xiuying: 1 article (01/2013)
7.	Christian, Kyle: 1 article (06/2004)
8.	Lang, Matti: 1 article (06/2004)
9.	Maurel, Patrick: 1 article (06/2004)
10.	Raffalli-Mathieu, Françoise: 1 article (06/2004)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1997 - "To clarify the mechanism underlying the male preference of liver tumor in transforming growth factor (TGF) alpha transgenic mice, we analyzed the sexually dimorphic expression of two P450s, i.e., female-specific mouse 15 alpha hydroxylase P450 (2A4) and coumarin 7-hydroxylase P450 (2A5). " 06/01/2004 - "The human xenobiotic-metabolizing enzyme cytochrome P450, CYP2A6, catalyzes the bioactivation of a number of carcinogens and drugs and is overexpressed in cases of liver diseases, such as cirrhosis, viral hepatitis, and parasitic infestation, and in certain tumor cells. "
2.	Necrosis 06/30/1984 - "Since pulmonary coumarin 7-hydroxylase has been shown to reside almost exclusively in the Clara cells, this finding is in agreement with the observed extensive necrosis of the Clara cells. " 01/01/1995 - "At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15 alpha-hydroxylase increase concomitant with prominent diffuse cell necrosis. "
3.	Non-alcoholic Fatty Liver Disease 01/01/2013 - "It is shown that hepatic CYP2A5 mRNA, protein expression and coumarin 7-hydroxylase activity are enhanced with high-fat feed, and that pyrazole is able to further increase CYP2A5 expression and activity in mice with NAFLD. "
4.	Lung Injury 08/01/1997 - "3. Pulmonary coumarin hydroxylase activity was greater in DBA than in BALB/c mice but the severity of BHT-induced lung injury was similar. " 08/01/1997 - "4. Pre-treatment with pyrazole, which exacerbated BHT-induced lung injury, did not affect pulmonary coumarin hydroxylase or 4-nitrophenol hydroxylase activity but increased that of PROD. "
5.	Periodontitis 06/01/2022 - "To investigate the relationship between polymorphism of cytochrome P450, family 2, subfamily A, polypeptide 6(CYP2A6) and periodontitis, the expression of inflammatory cytokines in 123 Han smokers. "

Related Drugs and Biologics

1.	Mixed Function Oxygenases (Monooxygenases)
2.	pyrazole
3.	Cytochrome P-450 CYP2B1 (PROD)
4.	Transforming Growth Factor alpha (TGF-alpha)
5.	Cytokines
6.	Transforming Growth Factors (Transforming Growth Factor)
7.	Xenobiotics
8.	Testosterone (Sustanon)
9.	Messenger RNA (mRNA)
10.	Proteins (Proteins, Gene)