Chikungunya Fever

An acute infection caused by a mosquito-borne alphavirus CHIKUNGUNYA VIRUS characterized by RASH; FEVER; JOINT PAINS; CONJUNCTIVITIS; MENINGOENCEPHALITIS; LYMPHOPENIA; and THROMBOCYTOPENIA.

Also Known As:

Chickungunya Fever; Chikungunya Virus Infection; Chickungunya Fevers; Chikungunya Fevers; Chikungunya Virus Infections; Fever, Chickungunya; Fever, Chikungunya; Infection, Chikungunya Virus

Networked: 203 relevant articles (5 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Virus Diseases: 41777
  - RNA Virus Infections: 303
    - Togaviridae Infections: 5
      - Alphavirus Infections: 249
        Chikungunya Fever: 203
  - Arbovirus Infections: 98
    - Chikungunya Fever: 203
- Vector Borne Diseases: 374
  - Mosquito-Borne Diseases: 229
    - Alphavirus Infections: 249
      - Chikungunya Fever: 203
  - Arbovirus Infections: 98
    - Alphavirus Infections: 249
      - Chikungunya Fever: 203

Related Diseases

1.	Arthritis (Polyarthritis)
2.	Neutropenia
3.	Infectious Arthritis (Septic Arthritis)
4.	Infections
5.	Dengue (Dengue Fever)

Experts

1.	Chu, Justin Jang Hann: 6 articles (02/2022 - 01/2010)
2.	Merits, Andres: 6 articles (03/2021 - 11/2014)
3.	Ng, Lisa F P: 6 articles (01/2019 - 01/2009)
4.	Chirathaworn, Chintana: 5 articles (09/2022 - 02/2010)
5.	Poovorawan, Yong: 5 articles (09/2022 - 02/2010)
6.	Weaver, Scott C: 5 articles (02/2017 - 07/2011)
7.	Roques, Pierre: 4 articles (01/2018 - 09/2013)
8.	Smith, Duncan R: 4 articles (01/2018 - 01/2015)
9.	Mahalingam, Suresh: 4 articles (01/2017 - 11/2013)
10.	Taylor, Adam: 4 articles (01/2017 - 11/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chikungunya Fever:

1.	Antiviral Agents (Antivirals)IBA 03/01/2018 - "The current study was undertaken to standardize assays for the study of these siddha formulations and to check their efficacy and potential mode of action as antivirals for Chikungunya virus infection in in vitro system. " 11/09/2023 - "Antiviral, Cytoprotective, and Anti-Inflammatory Effect of Ampelozizyphus amazonicus Ducke Ethanolic Wood Extract on Chikungunya Virus Infection." 11/01/2020 - "Chikungunya virus infection induces differential inflammatory and antiviral responses in human monocytes and monocyte-derived macrophages." 01/01/2018 - "The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies." 10/01/2013 - "Since the pharmacophore model is developed based on Chikungunya virus-host interaction, it can be used for designing promising antiviral lead compounds for the treatment of Chikungunya fever.An"
2.	VaccinesIBA 12/23/2022 - "Understanding the Biology and Immune Pathogenesis of Chikungunya Virus Infection for Diagnostic and Vaccine Development." 09/06/2022 - "The proposed designed vaccine construct may proceed with experimental testing for further efficacy verification and the final development of a vaccine against chikungunya virus infection." 09/06/2022 - "There is currently no commercially available drug or vaccine for chikungunya virus infection and the treatment is performed by symptom reduction. " 10/23/2020 - "Presently, there are no treatment strategies or vaccine for Chikungunya fever. " 01/01/2020 - "Current Efforts in the Development of Vaccines for the Prevention of Zika and Chikungunya Virus Infections."
3.	Antirheumatic Agents (DMARD)IBA 06/01/2017 - "In this randomized parallel group open label study of 24 weeks duration, we evaluated the efficacy of DMARD combination in persistent CA. Consecutive 139 patients with persistent CA (persistent arthritis for >1 year after the chikungunya fever either in 2008 or 2009 fulfilling epidemiological criteria for CA) were screened. "
4.	andrographolideIBA 01/01/2021 - "Andrographolide Mitigates Unfolded Protein Response Pathway and Apoptosis Involved in Chikungunya Virus Infection." 09/18/2015 - "Activity of andrographolide against chikungunya virus infection." 10/01/2021 - "Andrographolide - A prospective remedy for chikungunya fever and viral arthritis."
5.	MorpholinosIBA 07/30/2015 - "Antiviral Phosphorodiamidate Morpholino Oligomers are Protective against Chikungunya Virus Infection on Cell-based and Murine Models."
6.	Filgrastim (Neupogen)FDA Link 12/01/2021 - "A Rare Case of Severe Neutropenia Due to Chikungunya Fever Which Improved With Filgrastim."
7.	Immunoglobulin M (IgM)IBA 01/01/2017 - "The neutralizing role of IgM during early Chikungunya virus infection." 06/01/2016 - "Out of the 723 acute phase samples tested from three geographical locations of India, Chikungunya virus infection was detected in 249/723 (34.44%) subjects by either IgM Elisa (180/723) or RT-PCR (69/412). " 11/01/2012 - "IgM capture ELISA, an in house reverse transcription PCR for the diagnosis of Chikungunya fever, TaqMan real-time PCR, and a one step reverse transcription-loop mediated isothermal amplification assay (RT-LAMP). " 11/01/2012 - "Utility of IgM ELISA, TaqMan real-time PCR, reverse transcription PCR, and RT-LAMP assay for the diagnosis of Chikungunya fever." 01/01/2012 - "52 children with chikungunya fever, confirmed by positive IgM antibody test were seen during 2009-2010. "
8.	AntibodiesIBA 01/01/2023 - "Equine Polyclonal Antibodies Prevent Acute Chikungunya Virus Infection in Mice." 06/15/2013 - "An essential role of antibodies in the control of Chikungunya virus infection." 01/01/2022 - "We performed the first study in northern Peru to describe the detection of SARS-CoV-2 IgM antibodies in febrile patients with a suspected diagnosis of dengue and chikungunya fever. " 01/01/2021 - "The persistence of serum-specific anti-chikungunya IgM antibodies (CHIKV-IgM) can vary after chikungunya fever (CHIK) infection. " 12/10/2009 - "Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies."
9.	Biomarkers (Surrogate Marker)IBA 09/01/2017 - "Wide varieties of the mucocutaneous manifestations were observed in our study, but the striking nose pigmentation was present irrespective of age and this peculiar pigmentation may be considered as a specific clinical marker of chikungunya fever. " 01/01/2023 - "High levels of cardiovascular biomarkers in fatal Chikungunya virus infection." 01/01/2021 - "Currently, there are no biomarkers for Chikungunya fever (CHIK) in clinical practice that can accurately predict the severity or chronification of the disease. " 01/01/2021 - "Biomarkers of severity and chronification in chikungunya fever: a systematic review and meta-analysis." 02/01/2012 - "Putative biomarkers in cases of chikungunya fever during an outbreak in the southern part of Thailand in 2009-2010 were identified. "
10.	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/01/2022 - "This study was performed during a chikungunya infection epidemic in Kassala, Sudan by recruiting all pregnant women with a confirmed chikungunya fever diagnosis by using antibodies/detection viral RNA using reverse transcriptase-polymerase chain reaction. " 04/01/2021 - "From September 2014 to July 2016, a surveillance study enrolled patients with acute febrile illness in Salvador, Brazil, and detected those with chikungunya virus infection using IgM enzyme-linked immunosorbent assay or reverse transcriptase polymerase chain reaction. "

Therapies and Procedures

1.	Oral Administration 04/01/2019 - "This study revealed the probable interactions after the oral administration of tender leaves of Glycosmis in preventing the chikungunya virus infection and paves the path for designing future plant-based drugs." 04/01/2019 - "Oral administration of tender leaf extract of Glycosmis pentaphylla is traditionally known to prevent the chikungunya virus infection. "
2.	Therapeutics 09/01/2013 - "Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy." 08/15/2009 - "Prophylaxis and therapy for Chikungunya virus infection." 12/01/2017 - "To review evidence of neurological manifestations in Chikungunya fever and map their epidemiology, clinical spectrum, pathomechanisms, diagnostics, therapies and outcomes. " 01/01/2019 - "This case reports for the first time the successful administration of intravenous immunoglobulin therapy to a patient with severe atypical dermatological form of Chikungunya Fever without any associated comorbidity." 01/01/2015 - "Previous reports suggest that chikungunya fever-related uveitis responds well to corticosteroid therapy. "
3.	Critical Care (Surgical Intensive Care) 01/01/2018 - "During the 2014-2015 chikungunya outbreak in French Polynesia, 64 patients with confirmed chikungunya virus infection were admitted into intensive care. " 01/01/2018 - "Intensive Care Admissions for Severe Chikungunya Virus Infection, French Polynesia." 09/01/2008 - "Serious acute chikungunya virus infection requiring intensive care during the Reunion Island outbreak in 2005-2006."
4.	Blood Transfusion (Blood Transfusions) 08/01/2014 - "Asymptomatic Chikungunya fever (CHIKF)-viremic blood donors could be a potential threat of spreading the disease unwittingly through contaminated blood transfusions. " 08/01/2014 - "The risk of blood transfusion-associated Chikungunya fever during the 2009 epidemic in Songkhla Province, Thailand." 10/01/2013 - "Viremic profiles in asymptomatic and symptomatic chikungunya fever: a blood transfusion threat?"
5.	Biological Therapy 11/14/2022 - "Treatment with biological therapy is associated with faster recovery and lower frequency of treatment switch among rheumatic patients with Chikungunya fever." 03/01/2016 - "Chikungunya virus infection in patients on biotherapies."