Squamous Intraepithelial Lesions of the Cervix

A cytological test finding often from PAP SMEARS that shows abnormal lesions of SQUAMOUS EPITHELIAL CELLS of the CERVIX. It is a diagnostic criterion used in the Bethesda System for UTERINE CERVICAL NEOPLASMS and represents the PAP TEST result that is abnormal. Although squamous intraepithelial lesions test result does not mean UTERINE CERVICAL NEOPLASMS it requires follow-ups (e.g., HPV DNA TESTS; and COLPOSCOPY).

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Uterine Cervical Neoplasms (Cancer of the Cervix)
2.	Carcinogenesis
3.	Necrosis
4.	Infections

Experts

1.	Khan, Mohsin: 1 article (01/2019)
2.	Misra, Jata S: 1 article (01/2019)
3.	Raza, Syed: 1 article (01/2019)
4.	Singh, Urmilla: 1 article (01/2019)
5.	Srivastava, Anand N: 1 article (01/2019)
6.	Annunziata, Clorinda: 1 article (01/2016)
7.	Buonaguro, Franco Maria: 1 article (01/2016)
8.	Comar, Manola: 1 article (01/2016)
9.	Stellato, Giovanni: 1 article (01/2016)
10.	Tornesello, Maria Lina: 1 article (01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Squamous Intraepithelial Lesions of the Cervix:

1.	CytokinesIBA 01/01/2016 - "A panel of 48 cytokines and growth factors were explored in a selected cohort of 168 immunocompetent women including 88 diagnosed with low (LSIL) or high (HSIL) squamous intraepithelial lesions of the cervix and 80 with normal cervical cytology (NIL). " 04/01/1999 - "Expression of MHC class II (HLA-A-DR and -DQ), costimulatory/adhesion molecules (CD11a/18, CD50, CD54, CD58 and CD86) and cytokines (tumour necrosis factor-alpha (TNF-alpha) and IL-10) was therefore investigated by immunohistochemistry in normal squamous epithelium (n = 12), low-grade (n = 23) and high-grade (n = 18) squamous intraepithelial lesions of the cervix. "
2.	Keratin-14 (Keratin 14)IBA 12/01/2001 - "Loss of cytokeratin 14 expression is related to human papillomavirus type and lesion grade in squamous intraepithelial lesions of the cervix."
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/01/2016 - "A panel of 48 cytokines and growth factors were explored in a selected cohort of 168 immunocompetent women including 88 diagnosed with low (LSIL) or high (HSIL) squamous intraepithelial lesions of the cervix and 80 with normal cervical cytology (NIL). "
4.	CD36 AntigensIBA 01/01/1994 - "Expression of the myelomonocytic antigens CD36 and L1 by keratinocytes in squamous intraepithelial lesions of the cervix."
5.	HLA-A Antigens (HLA-A)IBA 04/01/1999 - "Expression of MHC class II (HLA-A-DR and -DQ), costimulatory/adhesion molecules (CD11a/18, CD50, CD54, CD58 and CD86) and cytokines (tumour necrosis factor-alpha (TNF-alpha) and IL-10) was therefore investigated by immunohistochemistry in normal squamous epithelium (n = 12), low-grade (n = 23) and high-grade (n = 18) squamous intraepithelial lesions of the cervix. "
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/01/1999 - "Expression of MHC class II (HLA-A-DR and -DQ), costimulatory/adhesion molecules (CD11a/18, CD50, CD54, CD58 and CD86) and cytokines (tumour necrosis factor-alpha (TNF-alpha) and IL-10) was therefore investigated by immunohistochemistry in normal squamous epithelium (n = 12), low-grade (n = 23) and high-grade (n = 18) squamous intraepithelial lesions of the cervix. "
7.	Tumor Biomarkers (Tumor Markers)IBA 01/01/2019 - "AgNOR Pleomorphic Count as a Tumor Marker in Cervical Carcinogenesis and Feasibility of Its Introduction in Cervical Cancer Screening Programs to Discriminate High-Risk Cases of Squamous Intraepithelial Lesions of the Cervix."
8.	Insulin-Like Growth Factor I (IGF-1)IBA 08/15/2003 - "Serum levels of insulin-like growth factor I and risk of squamous intraepithelial lesions of the cervix."
9.	DNA (Deoxyribonucleic Acid)IBA 09/01/1996 - "Human papillomavirus DNA detection in cervical specimens by hybrid capture: correlation with cytologic and histologic diagnoses of squamous intraepithelial lesions of the cervix."
10.	Oral ContraceptivesIBA 07/01/1999 - "Risk factors for squamous intraepithelial lesions of the cervix are infection with the sexually acquired human papillomavirus (HPV), an early age at first intercourse, history of multiple sexual partners, oral contraceptive use, high parity, lower socioeconomic status, poor diet, immunosuppression, and promiscuous male sexual partners. "

Therapies and Procedures

1.	Laser Therapy (Surgery, Laser) 11/01/1998 - "A randomized clinical trial of cryotherapy, laser vaporization, and loop electrosurgical excision for treatment of squamous intraepithelial lesions of the cervix."
2.	Cryotherapy (Therapy, Cold) 11/01/1998 - "A randomized clinical trial of cryotherapy, laser vaporization, and loop electrosurgical excision for treatment of squamous intraepithelial lesions of the cervix."
3.	Lasers (Laser) 12/25/1998 - "Distinct cytogenetic alterations in squamous intraepithelial lesions of the cervix revealed by laser-assisted microdissection and comparative genomic hybridization."