Corneal Injuries

Damage or trauma inflicted to the CORNEA by external means.

Also Known As:

Cornea Injuries; Corneal Damage; Corneal Scar; Corneal Trauma; Abrasion, Corneal; Cornea Injury; Corneal Abrasion; Corneal Damages; Corneal Injury; Corneal Scars; Corneal Traumas; Damage, Corneal; Injury, Cornea; Injury, Corneal; Scar, Corneal; Trauma, Corneal; Corneal Abrasions

Networked: 1683 relevant articles (95 outcomes, 176 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Wounds and Injuries (Trauma)
3.	Inflammation (Inflammations)
4.	Astigmatism
5.	Dry Eye Syndromes (Dry Eye Syndrome)

Experts

1.	Wilson, Steven E: 10 articles (01/2022 - 08/2009)
2.	Nagai, Noriaki: 10 articles (01/2021 - 09/2009)
3.	Goswami, Dinesh G: 8 articles (01/2022 - 01/2016)
4.	Tewari-Singh, Neera: 8 articles (01/2022 - 01/2016)
5.	Jhanji, Vishal: 7 articles (05/2022 - 08/2012)
6.	Agarwal, Rajesh: 7 articles (01/2022 - 01/2016)
7.	Kant, Rama: 7 articles (01/2022 - 02/2016)
8.	Sharma, Namrata: 7 articles (01/2021 - 03/2006)
9.	Tsubota, Kazuo: 7 articles (12/2017 - 02/2007)
10.	Chinnery, Holly R: 6 articles (04/2022 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Corneal Injuries:

1.	Ophthalmic Solutions (Eye Drops)IBA 01/01/2023 - "Moreover, given that KCl eye drops can prevent corneal scar formation, it has been suggested to have huge prospects as a novel treatment approach during clinical practice." 10/24/2022 - "rhEGF eyedrops were safe and well-tolerated in healthy subjects in a dose range of 10-100 μg/mL, indicating suitability for further studies in patients with corneal injury." 01/01/2021 - "To the best of our knowledge, this is the first report of a study based on dihydropyrimidinthione derivatives to develop a promising eye drops, which may well find extensive applications in UV-B caused corneal damage." 01/01/2021 - "However, the multi-instillation of these three eye drops causes corneal damage, and the FL drops have the disadvantage of low ocular bioavailability. " 01/01/2020 - "Corneal damage necessitates the discontinuation of treatment with ophthalmic solutions. "
2.	Ointments (Pastes)IBA 07/01/1965 - "[Experimental studies on the corneal damage by the ophthalmic ointment and oil]." 11/01/2012 - "Although prevention has appeared feasible, inconsistent use and timing of conventional eye ointment and eyelid tape had failed to adequately prevent intraoperative corneal injuries at a department of anesthesiology in an academic medical center. " 09/01/1998 - "Topical ointment does not prevent recurrent symptoms following traumatic corneal abrasion." 06/01/1998 - "During general anaesthesia eyes need protection either by tape or ointment as incidence of corneal injuries is greater in unprotected eyes." 09/12/2012 - "In a UK study with 42 participants, lubricating ointment at night in addition to standard treatment to prevent recurrence following traumatic corneal abrasion (erosion) caused by fingernail injury led to increased symptoms of recurrent corneal erosion compared to standard therapy alone. "
3.	Analgesics (Analgesic Drugs)IBA 02/01/1994 - "MS showed an analgesic efficacy of 4.3-fold and 5.5-fold greater than the baseline or saline on the eye with corneal abrasion. " 02/01/1994 - "In a subsequent masked study, the analgesic efficacy of topical MS was assessed in seven patients with unilateral corneal abrasion. " 03/27/2017 - "For this review, ten published randomized controlled trials were identified, focusing on the efficacy and safety of different topical analgesics used in treating corneal abrasions. " 12/01/2018 - "If a severe ophthalmodynia that cannot be controlled using analgesics occurs immediately after surgery in the beach-chair position, a corneal injury should be suspected, and the patient should wear a corneal protective lens. " 02/01/1994 - "In contrast, MS showed an analgesic effect as early as 10 minutes after application in the eye with corneal abrasion. "
4.	AlkaliesIBA 09/01/2016 - "In conclusion, MSCs-CsA nanofibers were effective in the treatment of severe alkali-induced corneal injury. " 01/01/2021 - "Numerous studies have focused on studying the effect of drugs on alkali-induced corneal injury in mouse, but fewer on the involvement of alkali-induced DNA methylation and the PI3K/AKT/mTOR signaling pathway in the mechanism of alkali-induced corneal injury. " 10/05/2020 - "In vivo study was conducted utilizing an alkali-induced corneal injury rabbit model. " 08/15/2018 - "The alkali-induced corneal injury is an ocular emergency that required an immediate and effective management to preserve the normal corneal functions and transparency. " 07/21/2014 - "The alkali-burned corneal damage model in rats demonstrated that the biomimetic membranes could markedly improve re-epithelialization in corneal tissue within one week. "
5.	Tetracaine (Amethocaine)FDA LinkGeneric 04/01/2023 - "Three scenarios were presented involving the addition of tetracaine in addition to usual care in the setting of uncomplicated corneal abrasion. " 04/01/2014 - "Dogma challenged: tetracaine for corneal abrasions?" 01/01/2009 - "To assess whether topical 0.4% amethocaine self-administered to a maximum recommended frequency of once every hour for 36-48 h is safe in the management of uncomplicated corneal injury in patients discharged from the ED. " 06/01/1984 - "At 20 min after instillation of 1.0% Amethocaine HCl, the corneal damage threshold was significantly decreased. " 01/01/2021 - "Short-Term Topical Tetracaine Is Highly Efficacious for the Treatment of Pain Caused by Corneal Abrasions: A Double-Blind, Randomized Clinical Trial."
6.	Hyaluronic Acid (Hyaluronan)IBA 05/01/2010 - "Chemically modified and cross-linked derivative of hyaluronan improved corneal wound healing and could be useful for treating noninfectious corneal injuries." 11/01/1998 - "The distribution of hyaluronan (HA) and the cellular response after photokeratitis induced by different ultraviolet (UV) wavelengths in the rabbit cornea was examined to help understand the mechanism of corneal injury and repair after UV damage. " 11/01/1986 - "The non-Healon group had a higher incidence of corneal damage from the YAG laser and, as a result, a higher incidence of endothelial corneal decompensation than the patients with the Healon-filled chamber." 07/01/2010 - "Corneal damage was reduced in all treated groups with respect to CTRL+. This effect was statistically significant after 3 days when the emulsion alone or in combination with sodium hyaluronate was used, while hyaluronate improved this clinical sign after 7 days. " 10/01/2021 - "Efficacy of Long-term Use of 0.3% Sodium Hyaluronate Eye Drops for Traumatic Corneal Abrasion: A Randomized Controlled, Pilot Trial."
7.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/01/2017 - "The findings of the included studies do not provide strong evidence to support the use of topical NSAIDs in traumatic corneal abrasions. " 05/01/2005 - "To be included, studies had to be RCTs evaluating topical NSAIDs in traumatic corneal abrasions. " 01/01/2003 - "The search identified 3 studies not included in the previously published review of ophthalmic NSAIDs, yielding a total of 5 blinded, randomized, placebo-controlled trials involving NSAIDs for corneal abrasions. " 03/27/2017 - "Thus, this evidence supports the use of topical NSAIDs in the standard management of corneal abrasions. " 01/01/2017 - "It is therefore important to document the clinical efficacy and safety profile of topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) in the management of traumatic corneal abrasions. "
8.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2022 - "We included randomized controlled trials (RCTs) comparing antibiotic with another antibiotic or placebo in children and adults with corneal abrasion due to any cause. " 05/12/2022 - "Most patients with a corneal injury are administered anti-inflammatory medications and antibiotics, but no other treatments are currently available. " 01/01/2022 - "There is a need for a well-designed RCT assessing the efficacy and safety of ocular antibiotics in the treatment of corneal abrasion with a particular focus on high-risk populations and formulation of interventions." 01/01/2022 - "Ocular antibiotics are one of the management options for corneal abrasion. " 03/01/2015 - "Case Report A healthy 55-years-old male went to emergency due to a white infiltrate in the left eye without corneal trauma which partially responds to antibiotic treatment. "
9.	Dexamethasone (Maxidex)FDA LinkGeneric 04/01/2019 - "This novel surgical management of a dexamethasone implant dislocation into the anterior chamber was successful and resulted in no long-term corneal damage when the implant was removed without delay. " 04/01/2005 - "Dexamethasone was prophylactically and therapeutically effective in this inflammation model of dry eye, restoring tear function and inhibiting corneal injury following topical ocular application. " 04/01/2005 - "Preservation of tear film integrity and inhibition of corneal injury by dexamethasone in a rabbit model of lacrimal gland inflammation-induced dry eye." 01/01/2000 - "Our study shows that propolis has an anti-inflammatory effect comparable to dexamethasone in chemical corneal injury." 07/20/2023 - "Nitrogen mustard-induced ex vivo human cornea injury model and therapeutic intervention by dexamethasone."
10.	Naltrexone (ReVia)FDA LinkGeneric 04/01/2008 - "A 5-mm corneal abrasion at 9 or 11 weeks was treated topically for 7 days (4 times daily) with naltrexone or a sterile vehicle. " 09/15/2012 - "High dosages of naltrexone are effective in reversing dry eye and accelerating the repair of corneal abrasions in normal and diabetic rats; these studies are under investigation in the clinical setting. " 02/15/2010 - "This study examined the efficacy of naltrexone (NTX), a long-acting, potent opioid antagonist, applied topically, to facilitate the repair of standardized corneal abrasions in diabetic (alloxan-induced) New Zealand White rabbits (glucose levels>450 mg/dL). "

Therapies and Procedures

1.	Contact Lenses 07/01/2017 - "Consecutive case series of children treated successfully with "piggy-back" (PB) contact lens systems after corneal trauma. " 09/01/2018 - "Visual acuity improved from 0.66 logarithm of minimal angle of resolution (logMAR) to 0.19 logMAR with contact lens wear in eyes with a corneal scar (P<0.001). " 07/01/2017 - "Improved Vision and Contact Lens Wear Time With Piggy-Back Contact Lens Systems in Children After Penetrating Corneal Trauma." 05/01/2014 - "No other factors (age, corneal scar location/density, grade/zone of injury, lens status, and occlusion) seemed to affect visual improvement with contact lenses. " 04/01/2013 - "To evaluate the efficacy of contact lenses in visual rehabilitation of a series of patients with corneal scars/opacities. "
2.	Corneal Transplantation (Keratoplasty) 12/01/2021 - "Corneal transplantation is the main treatment for serious corneal damage, but it faces significant challenges, including donor shortages and severe complications. " 03/01/2017 - "Endothelial keratoplasty is at present the gold standard for surgical treatment of corneal endothelial pathologies not associated with significant corneal scar. " 06/21/2009 - "microkeratome-assisted anterior lamellar keratoplasty seems to be safe and effective to remove corneal scars and reduce high degree irregular astigmia, moreover, to improve visual acuity." 05/01/1996 - "PTK is a relatively safe and effective means of treating corneal scars and thereby may offer an alternative to corneal transplantation." 01/01/2022 - "In this single-center study, 41 consecutive eyes with traumatic corneal scars that underwent 2-piece microkeratome-assisted mushroom keratoplasty were evaluated. "
3.	Therapeutics 10/01/2023 - "At present, no specific therapy exists to mitigate SM-induced corneal injury and vision loss. " 03/01/2023 - "Although ocular exposure to SM vapor continues to be a challenging therapeutic target, establishing consistent and reproducible models of corneal injury that enhance mechanistic and pathophysiological understanding will help satisfy regulatory requirements and accelerate the development of effective therapies." 10/21/2022 - "Recent Advancements in Molecular Therapeutics for Corneal Scar Treatment." 01/01/2021 - "Further explorations of its potential as adjuvant therapy in treating corneal injuries are needed. " 10/01/2019 - "These clinical, biological, and molecular markers could be useful for the evaluation of acute corneal injury and to screen for therapies against NM- and SM-induced ocular injury."
4.	Hydrophilic Contact Lenses (Hydrophilic Contact Lens) 05/01/2022 - "The Protective Effects of Soft Contact Lenses for Contact Sports: A Novel Porcine Model for Corneal Abrasion Biomechanics." 10/01/1989 - "The results of this study indicate that the thickness of a soft contact lens is important in treating corneal trauma." 12/01/2022 - "Corneal injury by plant material, and soft contact lens use were the main risk factors (42.8% and 31.4%, respectively). " 05/01/2022 - "With soft contact lens barrier, the maximum measurable force of 50 Newtons could not produce a corneal abrasion. " 09/01/2012 - "A 52-year-old soft contact lens wearer had a corneal abrasion and developed a corneal infiltrate. "
5.	Sutures (Suture) 06/01/2021 - "A 23-year-old male suffered a penetrating corneal injury that was treated with sutures. " 01/01/2021 - "Full- versus partial-thickness sutures: experimental models of corneal injury repair." 09/22/2020 - "Intraoperative IOP fluctuations and extra corneal damage can be avoided by lens preparation with the sutures using a small incision ab-externo approach." 01/01/2020 - "These results suggest that the eye is most susceptible to corneal damage around the suture area especially with a straight-gaze impact by an air gun, and that special precautionary measures should be considered in patients who undergo PKP. " 03/01/2015 - "Potential complications of this technique include superficial skin erosion of the upper lid, corneal abrasion, and blockage of the field of vision while the suture is in place."