Efficacy of Long-term Use of 0.3% Sodium Hyaluronate Eye Drops for Traumatic Corneal Abrasion: A Randomized Controlled, Pilot Trial.

Abstract

PURPOSE:

Traumatic corneal abrasion (TCA) causes damage to both corneal epithelium and the underlying hemidesmosomal junctions. Delayed recovery of hemidesmosomal junctions causes symptomatic episodes. However, there is no recommended treatment for recovery of hemidesmosomal junctions, indicating that a blank period exists in TCA treatment. In this study, the efficacy of long-term use of sodium hyaluronate on recovery of hemidesmosomal junctions during the blank period in TCA healing was investigated.

METHODS:

In this prospective, randomized control pilot study, 60 patients with TCA were enrolled. The patients were randomized 1:1 to receive 0.3% sodium hyaluronate eye drops for 3 months (HA group) or observation alone (control group) after complete corneal epithelium recovery. The primary and secondary outcomes were the cumulative incidence of major and minor symptomatic episodes during a 12-month follow-up, respectively.

RESULTS:

Fifty-six subjects (29 in the HA group and 27 in the control group) completed the 12-month follow-up. The 12-month cumulative incidence rate of major symptomatic episodes was 20.7% in the HA group and 18.5% in the control group. No significant difference was found between the 2 groups (P = 0.838). The 12-month cumulative incidence rate of minor symptomatic episodes was 48.3% and 37.0% in the HA and control groups, respectively, with no significant difference (P = 0.397).

CONCLUSIONS:

Approximately one-fifth of patients with TCA experience major symptomatic episodes again within their 1-year follow-up. Long-term use of sodium hyaluronate in the period of recovery of hemidesmosomal junctions has no benefit to it.

• Authors: Menghuan Wei, Yingshi Zou, Fang Duan, Xiaohu Ding, Jiejie Zhuang, Jiayu Deng, Zhaohui Yuan
• Journal: Cornea (Cornea) Vol. 40 Issue 10 Pg. 1248-1252 (Oct 01 2021) ISSN: 1536-4798 [Electronic] United States
• PMID: 33369934 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Ophthalmic Solutions
• Viscosupplements
• Hyaluronic Acid

Topics

• Administration, Ophthalmic
• Adult
• Corneal Injuries (drug therapy)
• Female
• Follow-Up Studies
• Hemidesmosomes (metabolism)
• Humans
• Hyaluronic Acid (administration & dosage)
• Male
• Middle Aged
• Ophthalmic Solutions (administration & dosage)
• Pilot Projects
• Prospective Studies
• Treatment Outcome
• Viscosupplements (administration & dosage)
• Wound Healing (drug effects)