Myxovirus Resistance Proteins

10/01/2008 - "However, Mx protein was highly expressed in Balb/c-Mx+-A2G mice with BA phenotype, but not in wild type Balb/c mice or disease-free Balb/c-Mx+-A2G mice despite RRV infection. "
12/01/2007 - "As Mx is known to provide protection against IPNV infections it is tempting to associate the duration of persistence of Mx protein with the outbreaks of IPN-related mortalities in post-smolts, 6-8 weeks after transfer to sea water."
11/01/2002 - "The cells were then studied for Mx protein expression and protection against infectious pancreatic necrosis virus (IPNV) infection. "
12/01/2012 - "One nonsynonymous substitution (S631N) in the chicken Mx protein is reported to be associated with resistance to AIV infection in vitro. "
06/01/2008 - "The antivirus assay showed that Mx protein had characteristics of resistance to infection of Newcastle Disease Virus. "

08/16/2010 - "The chicken Mx protein (Asn631) lacks inhibitory effects against THOV and NDV, and is unable to suppress influenza replication when artificially re-localised to the cell nucleus. "
08/01/1987 - "It was also demonstrated that p78 and the protein Mx of influenza-resistant mice, which we purified and characterized earlier (Horisberger and Hochkeppel, J. "
07/01/2012 - "We conclude, in contradiction to the hypothesis currently in vogue in the literature, that the GED is not the sole determinant controlling the magnitude of the anti-influenza activity exercised by an Mx protein that can bind GTP and multimerise. "
12/01/1990 - "Parental influenza virion nucleocapsids are efficiently transported into the nuclei of murine cells expressing the nuclear interferon-induced Mx protein."
03/01/2017 - "In this study, for the first time we explore the idea of using host interferon inducible Mx protein to increase the immunogenicity of HA2 H9N2 influenza DNA vaccine. "

01/01/2021 - "In this study, we found that grass carp (Ctenopharyngodon idella) MxG, a teleost-specific Mx protein, is induced by IFNs and viruses, and it negatively regulates both IPS-1- and STING-mediated antiviral responses to facilitate grass carp reovirus, spring viremia of carp virus, and cyprinid herpesvirus-2 replication. "

01/01/2021 - "In this study, we found that grass carp (Ctenopharyngodon idella) MxG, a teleost-specific Mx protein, is induced by IFNs and viruses, and it negatively regulates both IPS-1- and STING-mediated antiviral responses to facilitate grass carp reovirus, spring viremia of carp virus, and cyprinid herpesvirus-2 replication. "

10/01/2014 - "The myxovirus resistance protein (Mx) has been reported to confer resistance to Orthomyxo virus infection by modifying cellular functions needed along the viral replication pathway. "
09/01/2013 - "Mx protein is known to play an important role in vertebrate immune response to viral infection. "
04/01/2009 - "Moreover, we correlated our findings to the expression of Mx protein, which has been shown to be significantly up-regulated during viral infections. "
10/01/1989 - "Our results indicate that the Mx protein is a sensitive, quantitative, and stable marker to follow IFN activity or virus infection in an animal model."
08/28/2021 - "Developing a Virus-Binding Bacterium Expressing Mx Protein on the Bacterial Surface to Prevent Grouper Nervous Necrosis Virus Infection."