Orexin Receptors

G-protein-coupled NEUROPEPTIDE RECEPTORS that have specificity for OREXINS and play a role in appetite control, and sleep-wake cycles. Two principle receptor types exist, each having a specificity for OREXIN A and OREXIN B peptide subtypes.

Also Known As:

HCRT Receptor 1; HCRT Receptor 2; HCTR2 Protein; Hypocretin Receptor 2; Hypocretin Receptors; Hypocretin Receptors 2; Hypocretin-1 Receptor; Hypocretin-2 Receptor; OX1 Receptors; OX2 Receptors; Orexin A Receptor; Orexin B Receptor; Orexin Receptor 2; Orexin Receptor Type 1; Orexin Receptor Type 2; Orexin-A Receptor; Orexin-A Receptors; Orexin-B Receptor; Orexin-B Receptors; Receptor 2, Hypocretin; Receptor, Orexin-A; Receptor, Orexin-B; Hypocretin 1 Receptor; Hypocretin 2 Receptor; Orexin A Receptors; Orexin B Receptors; Protein, HCTR2; Receptor 1, HCRT; Receptor 2, HCRT; Receptor 2, Orexin; Receptor, Hypocretin; Receptor, Hypocretin-1; Receptor, Hypocretin-2; Receptor, OX1; Receptor, OX2; Receptor, Orexin; Receptor, Orexin A; Receptor, Orexin B; Receptors 2, Hypocretin; Receptors, Hypocretin; Receptors, OX1; Receptors, OX2; Receptors, Orexin; Receptors, Orexin-A; Receptors, Orexin-B; Hypocretin Receptor; OX1 Receptor; OX2 Receptor; Orexin Receptor

Networked: 317 relevant articles (12 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Haghparast, Abbas: 12 articles (01/2022 - 12/2012)
2.	Yanagisawa, Masashi: 11 articles (01/2022 - 03/2004)
3.	Sakurai, Takeshi: 9 articles (10/2017 - 03/2004)
4.	Coleman, Paul J: 8 articles (01/2017 - 01/2008)
5.	Renger, John J: 8 articles (01/2017 - 03/2010)
6.	Nishino, Seiji: 7 articles (01/2018 - 07/2003)
7.	Winrow, Christopher J: 7 articles (01/2017 - 04/2010)
8.	Gotter, Anthony L: 6 articles (01/2017 - 07/2012)
9.	Hoyer, Daniel: 5 articles (01/2022 - 01/2013)
10.	Irukayama-Tomobe, Yoko: 5 articles (01/2022 - 08/2015)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 07/01/2022 - "Novel compound with potent antagonistic activity against orexin receptors may be new treatment option for patients with insomnia. " 04/04/2023 - "This research enabled the discovery of a potential small-molecule antagonist of orexin receptors for the treatment of insomnia, providing a novel screening approach for the detection of potential candidate compounds for corresponding targets." 04/04/2023 - "Orexin receptors 1 (OX1R) and 2 (OX2R) are burgeoning targets for insomnia treatment. " 01/01/2023 - "Targeting Orexin Receptors for the Treatment of Insomnia: From Physiological Mechanisms to Current Clinical Evidence and Recommendations." 12/01/2022 - "The development of antagonists to orexin receptors has become important in drug discovery because modulation of these receptors can lead to novel treatments for diseases related to the regulation of sleep and wakefulness, such as insomnia. "
2.	Sleep Wake Disorders 09/08/2022 - "Novel 3-Aminopyrrolidine and Piperidine Macrocyclic Orexin Receptor Agonists for Treating Sleep Disorders." 07/14/2022 - "Novel Macrocyclic Urea Orexin Receptor Agonists for Treating Sleep Disorders." 11/12/2020 - "Novel 5-Alkyl Pyrrolidine Orexin Receptor Agonists for Treating Sleep Disorders." 01/01/2018 - "An example of a drug, which blocks orexin receptors and can be used as a hypnotic drug to treat sleep disorders, is presented. " 02/01/2013 - "Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. "
3.	Migraine Disorders (Migraine) 04/01/2015 - "This study explored whether antagonism of orexin receptors might be an effective mechanism for migraine prevention. " 04/01/2011 - "The aim of our study was to investigate whether genetic variants in the hypocretin receptor 1 (HCRTR1) gene could modify the occurrence and the clinical features of migraine. " 08/01/2007 - "Using a case-control design study, we genotyped 246 migraine patients and 239 healthy controls for the 1246G-->A polymorphism of the hypocretin receptor 2 (HCRTR2) gene. " 04/01/2011 - "Evidence for an association between migraine and the hypocretin receptor 1 gene." 09/01/2007 - "Association between migraine and the G1246A polymorphism in the hypocretin receptor 2 gene."
4.	Obesity 10/25/2019 - "Differential Roles of Each Orexin Receptor Signaling in Obesity." 12/01/2015 - "We hypothesized that alteration of orexin receptor in the paraventricular nucleus (PVN) of the hypothalamus leads to elevated sympathetic vasomotor tone in obesity. " 02/01/2013 - "Role of orexin receptors in obesity: from cellular to behavioral evidence." 02/15/2011 - "[Expression of orexin receptor 1 in rat pancreatic tissue with alimentary obesity]." 03/15/2002 - "This is the first demonstration that OX1 receptor antagonists have potential as both anti-obesity and anti-diabetic agents."
5.	Neoplasms (Cancer) 10/01/2017 - "In addition, its activation via the Ox1 receptor triggers apoptosis in several cancer cell lines. " 06/01/2013 - "The expression and distribution of the Orexin receptor was more widespread in Group 1 than in the other groups and was higher in patients with poorly differentiated malignancy. " 11/01/2016 - "Although increased expression of orexin receptor (OxR), known to be strongly expressed in human placenta, has a proven relation to some cancers , there have been few studies of cervical cancer. " 12/01/2013 - "Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders." 01/01/2018 - "Increasing evidence has indicated high expression of orexin-A and OX1 receptor (OX1R) in malignant tumors, suggesting that the stimulation of OX1R might be essential for tumorigenesis. "

Related Drugs and Biologics

1.	suvorexant
2.	MK-6096
3.	Orexins
4.	almorexant
5.	YNT-185
6.	Peptide Receptors (Peptide Receptor)
7.	Glucose (Dextrose)
8.	N- ((1- ((5- (4- fluorophenyl)- 2- methyl- 4- thiazolyl)carbonyl)- 2- piperidinyl)methyl)- 4- benzofurancarboxamide
9.	zuogui
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Analgesia
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Intraventricular Infusions