Nestin

A type VI intermediate filament protein expressed mostly in nerve cells where it is associated with the survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

Also Known As:

Networked: 1457 relevant articles (54 outcomes, 224 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ishiwata, Toshiyuki: 25 articles (01/2021 - 05/2006)
2.	Matsuda, Yoko: 23 articles (01/2021 - 01/2011)
3.	Hoffman, Robert M: 22 articles (03/2017 - 01/2004)
4.	Calderone, Angelino: 16 articles (01/2018 - 07/2005)
5.	Amoh, Yasuyuki: 16 articles (01/2013 - 06/2005)
6.	Naito, Zenya: 15 articles (04/2014 - 05/2006)
7.	Katsuoka, Kensei: 14 articles (01/2013 - 06/2005)
8.	Villeneuve, Louis: 12 articles (07/2017 - 07/2005)
9.	Veselska, Renata: 11 articles (07/2016 - 02/2006)
10.	Holland, Eric C: 10 articles (01/2017 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2021 - "Patients displaying high expression of nestin and CD34 demonstrated higher rates of T1 and T2 tumors (p = .020), lower vascular invasion (p < .001) and improved 5-year overall survival (65%; 95% CI = 55-73 vs 45%; 95% CI = 37-53) after adjusting for clinicopathological characteristics (HR: 0.67; 95% CI = 0.46-0.96). " 10/01/2013 - "Because the nestin expression pattern in each histological salivary gland tumor type is unique, nestin could be a very useful abluminal cell marker for the diagnosis of salivary gland tumors. " 01/01/2015 - "Thus the purpose of this study was to explore whether different expression level of cancer stem cell markers including CD29, CD44, CD133, nestin and ALDH1 in vascular tumor may help to elucidate the possible pathogenesis of vascular tumor. " 01/01/2021 - "Therefore, in the present study, we investigated how ERG and nestin were expressed with respect to tumor characteristics. " 05/01/2019 - "The present study comparatively analyzed serial autopsies of Japanese patients (n=2,206; males, 1,225; females, 981; median, 80.7 years old; range, 33-104 years old) with malignant tumors of whole organs, with respect to the clinical information, and 5 single nucleotide polymorphisms of the nestin gene. "
2.	Infarction (Infarctions) 01/01/2017 - "The administration of EA improved the rats' nerve-related abilities, remedied infarct volumes and morphological changes in the brain, and enhanced the content of nestin protein in the brain semidarkness zone. " 02/01/2012 - "After MCAO, vascular leakage and infarction volume in Nestin-KO were worse than controls, but partly improved compared with Esr-KO. " 04/15/2021 - "Sevo raised miR-490-5p and decreased CDK1 to improve neurological deficits, reduce apoptotic neurons, suppress expression levels of GFAP and Iba-1, and increase Nestin expression and the number of surviving neurons in peripheral tissue in infarct area, and alleviate the pathological changes of brain tissues of brain damage rats. " 01/01/2018 - "During the chronic phase of infarct healing, post-conditioned animals exhibited fewer myofibroblasts compared to control animals, even those derived from progenitor cells, i.e., α-smooth actin-nestin positive cells. " 01/01/2018 - "Cardiac resident neural progenitor/stem cells constitutively express nestin and following an ischemic insult migrate to the infarct region and participate in angiogenesis and neurogenesis. "
3.	Glioma (Gliomas) 03/01/2015 - "Nestin downregulation, for instance, dramatically reduced intracerebral glioma growth. " 10/01/2020 - "Furthermore, this finding seems at odds with better outcome of IDH1R132H glioma because of a negative association of nestin with overall survival. " 01/01/2017 - "Various studies examining the relationship between nestin expression with the clinical outcome in glioma patients have yielded inconclusive results. " 01/01/2017 - "Nestin Expression Is Associated with Poor Clinicopathological Features and Prognosis in Glioma Patients: an Association Study and Meta-analysis." 05/14/2015 - "19 studies and 13 studies investigated correlation between CD133 expression or Nestin and survival in gliomas, respectively. "
4.	Melanoma (Melanoma, Malignant) 10/01/2016 - "The present study examined the expression and prognostic significance of nestin in patients with primary mucosal melanoma of the oral cavity. " 01/01/2016 - "Studies are now indicated to further define the interplay between 5-hmC, nestin expression, and melanoma virulence." 03/01/2014 - "The aim of the present study was to evaluate the prognostic influence of nestin expression in cutaneous melanoma in comparison with standard clinico-pathologic variables. " 01/01/2013 - "Recent studies have demonstrated strong expression of neural stem/progenitor cell markers nestin and SOX2 in melanoma. " 01/01/2012 - "To study the effect of lentivirus-mediated RNA interference (RNAi) of nestin on the metastatic potential of human melanoma cell line UACC903. "
5.	Stroke (Strokes) 04/23/2012 - "Combination treatment of Stroke significantly improved the neurological functional recovery as early as 48 hours and up-regulated the SDF-1α /CXCR4 axis, enhanced BMSC migration into the ischemic brain and differentiation into Nestin-positive cells. " 12/01/2022 - "Spontaneous recovery after stroke was observed from day 2 to day 14 and was accompanied by a significantly higher expression of nestin, p-Akt, p-ERK1/2 and TGF-β in ischemic regions compared to contralateral side at day 14. " 01/01/2017 - "While in the baseline conditions the nestin signal and/or GFP expression was restricted to neuronal progenitors, the cellular expression patterns of nestin following innate immune challenge and after stroke markedly differed shifting the cellular expression patterns towards activated microglia/macrophages and astrocytes. " 01/12/2016 - "Rats administered 100K/bFGF on post-stroke day 1 exhibited a higher number of Ki67 and Nestin immunoreactive cells at the subventricular zone (SVZ) area and in the infarcted brain, indicating promotion of NSPCs proliferation. " 01/01/2015 - "Conditional deletion of the shh gene in nestin-expressing cells both at the SVZ niche and at the ischemic site lead to significantly more severe behavioral deficits in these shh iKO mice after cortical stroke, measured using an automated open field locomotion apparatus (Student's t-test, p<0.05). "

Related Drugs and Biologics

1.	Bromodeoxyuridine (BrdU)
2.	Tubulin
3.	Retinaldehyde (Retinal)
4.	Proteins (Proteins, Gene)
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Brain-Derived Neurotrophic Factor (BDNF)
7.	Small Interfering RNA (siRNA)
8.	Sirolimus (Rapamycin)
9.	Cytokines
10.	Caveolin 1

Related Therapies and Procedures

1.	Transplantation
2.	Therapeutics
3.	Lasers (Laser)
4.	Drug Therapy (Chemotherapy)
5.	Operative Surgical Procedures