Minichromosome Maintenance Complex Component 6

A minichromosome maintenance protein that is a key component of the six member MCM protein complex. It is also found in tightly-bound trimeric complex with MINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 4 and MINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 7.

Also Known As:

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Kai: 1 article (07/2021)
2.	Cheng, Cheng: 1 article (07/2021)
3.	Gu, Yaoyao: 1 article (07/2021)
4.	Hu, Xiaoxiao: 1 article (07/2021)
5.	Liu, Xiaowei: 1 article (07/2021)
6.	Wu, Yeming: 1 article (07/2021)
7.	Wu, Zhixiang: 1 article (07/2021)
8.	Chen, Suixia: 1 article (07/2020)
9.	Jia, Wenxian: 1 article (07/2020)
10.	Li, Hongwen: 1 article (07/2020)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 07/01/2020 - "Minichromosome maintenance complex component 6 (MCM6) is involved in tumorigenesis of hepatocellular carcinoma (HCC). " 12/01/2014 - "Plasma minichromosome maintenance complex component 6 is a novel biomarker for hepatocellular carcinoma patients." 12/01/2014 - "This study aimed to investigate the presence of plasma minichromosome maintenance complex component 6 (MCM6) mRNA and protein levels in hepatocellular carcinoma (HCC) patients and evaluate their diagnostic value for HCC. "
2.	Neoplasms (Cancer) 07/07/2021 - "Minichromosome maintenance complex component 6 (MCM6), as an important replication permission factor, is involved in the pathogenesis of various tumors. " 01/22/2018 - "Minichromosome maintenance complex component 6 (MCM6), which has been reported to up-regulate in multiple malignancies, was considered to be a novel diagnoses biomarker in HCC. " 01/01/2019 - "Cyclin-dependent kinase 5 regulatory subunit-associated protein 3 (CDK5RAP3) was identified as a tumor suppressor in gastric cancer, while, minichromosome maintenance complex component 6 (MCM6), which is closely related to the initiation of DNA replication, was reported to be upregulated in multiple malignancies. " 11/01/2014 - "Tumor protein 53 (TP53), TP63, Ki67, epidermal growth factor receptor (EGFR), minichromosome maintenance complex component 6 (MCM6), MCM7, uncharacterized proteins KIAA1522 and KIAA0317, and ubiquitin-protein ligase UHR1 (ICBP90) frequently presented high expression in bronchial brushing specimens from patients who had lung cancer compared with patients who had benign lung lesions. " 10/01/2015 - "The following genes appeared to be possibly related to the metastatic potential of the tumor: ELOVL fatty acid elongase 7 (ELOVL7), enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), gastrulation brain homeobox 2 (GBX2), golgi membrane protein 1 (GOLM1), homeobox C6 (HOXC6), minichromosome maintenance complex component 6 (MCM6), marker of proliferation Ki-67 (MKI67), mucin 1, cell surface associated (MUC1), MYC binding protein 2, E3 ubiquitin protein ligase (MYCBP2), somatostatin receptor 1 (SSTR1), topoisomerase (DNA) II alpha 170 kDa (TOP2A) and exportin 6 (XPO6). "
3.	Carcinogenesis 07/01/2020 - "Minichromosome maintenance complex component 6 (MCM6) is involved in tumorigenesis of hepatocellular carcinoma (HCC). "
4.	Stomach Neoplasms (Stomach Cancer) 01/01/2019 - "Cyclin-dependent kinase 5 regulatory subunit-associated protein 3 (CDK5RAP3) was identified as a tumor suppressor in gastric cancer, while, minichromosome maintenance complex component 6 (MCM6), which is closely related to the initiation of DNA replication, was reported to be upregulated in multiple malignancies. "
5.	Silicosis 06/06/2023 - "Seven hub genes (budding uninhibited by benzimidazoles 1 [BUB1], protein regulator of cytokinesis 1 [PRC1], kinesin family member C1 [KIFC1], ribonucleotide reductase regulatory subunit M2 [RRM2], cyclin-dependent kinase inhibitor 3 [CDKN3], Cyclin B2 [CCNB2], and minichromosome maintenance complex component 6 [MCM6]) were involved in the interaction between COVID-19 and silicosis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Messenger RNA (mRNA)
3.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
4.	Biomarkers (Surrogate Marker)
5.	DNA (Deoxyribonucleic Acid)
6.	ErbB Receptors (EGF Receptor)
7.	Minichromosome Maintenance Complex Component 7
8.	Polycomb Repressive Complex 2
9.	Cyclin B2
10.	Cyclin-Dependent Kinase 5