Minichromosome Maintenance Proteins

A family of proteins that were originally identified in SACCHAROMYCES CEREVISIAE as being essential for maintaining the structure of minichromosomes00. They form into a protein complex that has helicase activity and is involved in a variety of DNA-related functions including replication elongation, RNA transcription, chromatin remodeling, and genome stability.

Also Known As:

MCM Protein Complex; MCM2-7 Complex; MCM2-7 Helicase; Helicase, MCM2-7; MCM2 7 Complex; MCM2 7 Helicase; Maintenance Proteins, Minichromosome

Networked: 50 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dziegiel, Piotr: 4 articles (05/2019 - 12/2013)
2.	Coleman, Nicholas: 4 articles (09/2009 - 06/2002)
3.	Piotrowska, Aleksandra: 3 articles (05/2019 - 02/2016)
4.	Laskey, Ronald A: 3 articles (09/2009 - 06/2002)
5.	Jablonska, Karolina: 2 articles (05/2019 - 12/2013)
6.	Nowinska, Katarzyna: 2 articles (05/2019 - 02/2016)
7.	Podhorska-Okolow, Marzena: 2 articles (05/2019 - 12/2013)
8.	Passerini, Verena: 2 articles (11/2016 - 02/2016)
9.	Storchová, Zuzana: 2 articles (11/2016 - 02/2016)
10.	Pula, Bartosz: 2 articles (02/2016 - 12/2013)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2008 - "Improved screening for anal neoplasia by immunocytochemical detection of minichromosome maintenance proteins." 03/01/2019 - "The aim of this study was to evaluate the role of minichromosome maintenance proteins MCM-3, MCM-5, MCM-7, and Ki-67 as proliferative markers in adrenocortical tumors. " 08/01/2005 - "Minichromosome maintenance proteins 2 and 5 expression in muscle-invasive urothelial cancer: a multivariate survival study including proliferation markers and cell cycle regulators." 07/24/2023 - "The family of minichromosome maintenance proteins (MCM) improves the stability of genome replication by inhibiting the rate of DNA replication in eukaryotic cells, thus, small changes in physiological MCM levels would increase the instability of gene replication and increase the incidence of tumor formation, most of which are significantly elevated in multiple cancers. " 01/01/2023 - "Pan-Cancer Multi-Omics Analysis of Minichromosome Maintenance Proteins (MCMs) Expression in Human Cancers."
2.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 12/20/2005 - "The aim of this study was to assess the proliferative activity of diffuse large B-cell lymphoma (DLBCL) in tissue microarray (TMA) using one of the minichromosome maintenance proteins (Mcm2) and to explore its potential value to predict prognosis. "
3.	Ovarian Neoplasms (Ovarian Cancer) 12/01/2013 - "The present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type. " 12/01/2013 - "Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer."
4.	Colonic Neoplasms (Colon Cancer) 01/01/2018 - "This study investigated the possible interaction between RAD51 and minichromosome maintenance proteins (MCMs) in HCT116 cells, which can serve as a model system for forming colon cancer foci. "
5.	Genomic Instability 08/01/2014 - "The regulated loading of the replicative helicase minichromosome maintenance proteins 2-7 (MCM2-7) onto replication origins is a prerequisite for replication fork establishment and genomic stability. " 03/01/2012 - "Since MCM4 is one part of a MCM2-7 complex recently confirmed as the replicative helicase essential for normal DNA replication and genome stability in all eukaryotes, it is possible that our patients may have an increased risk of neoplastic change. " 02/15/2016 - "Strikingly, we find that aneuploidy-induced genomic instability can be explained by the reduced expression of the replicative helicase MCM2-7. " 03/01/2008 - "Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability." 02/01/2004 - "The MCM2-7 complex, which may act as a replicative helicase during DNA synthesis, plays a central role in S-phase genome stability. "

Related Drugs and Biologics

1.	Metallothionein
2.	Metallothionein 3
3.	Minichromosome Maintenance Proteins
4.	Biomarkers (Surrogate Marker)
5.	Sesquiterpenes
6.	Proteins (Proteins, Gene)
7.	cedrol
8.	Mediator Complex
9.	Cullin Proteins (Cullins)
10.	Neuropilin-1