Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors.

Abstract

BACKGROUND/AIM:

Morphological features, combined with Ki-67 proliferative index, remain the standard for discriminating benign and malignant adrenocortical tumors. The aim of this study was to evaluate the role of minichromosome maintenance proteins MCM-3, MCM-5, MCM-7, and Ki-67 as proliferative markers in adrenocortical tumors.

MATERIALS AND METHODS:

Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67.

RESULTS:

Malignant tumors were characterized by a greater size (p=0.017), volume (p=0.017), and higher levels of Ki-67 (p=0.005), MCM-3 (p=0.005), MCM-7 (p=0.008), but not MCM-5 (p=0.069). The markers' levels were independent from the tumors' size and volume, the patient's age and hormonal status. ROC curves showed Ki-67 (AUC 0.984), MCM-3 (AUC 0.984), and MCM-7 (AUC 0.950), but not MCM-5 (AUC 0.820) to be reliable markers.

CONCLUSION:

Ki-67, MCM-3, and MCM-7, but not MCM-5 are reliable proliferative and diagnostic markers in discerning benign and malignant adrenocortical tumors.

• Authors: Michal Aporowicz, Piotr Czopnik, Eliza Kubicka, Aleksandra Piotrowska, Piotr Dziegiel, Marek Bolanowski, Pawel Domoslawski
• Journal: Anticancer research (Anticancer Res) Vol. 39 Issue 3 Pg. 1151-1159 (Mar 2019) ISSN: 1791-7530 [Electronic] Greece
• PMID: 30842144 (Publication Type: Journal Article)
• Copyright: Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• Cell Cycle Proteins
• Ki-67 Antigen
• MCM3 protein, human
• MCM5 protein, human
• MCM7 protein, human
• Minichromosome Maintenance Complex Component 3
• Minichromosome Maintenance Complex Component 7

Topics

• Adenoma (diagnosis, metabolism)
• Adrenal Cortex Neoplasms (diagnosis, metabolism)
• Adrenocortical Carcinoma (diagnosis, metabolism)
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Cell Cycle Proteins (metabolism)
• Cell Proliferation
• Female
• Humans
• Ki-67 Antigen (metabolism)
• Male
• Middle Aged
• Minichromosome Maintenance Complex Component 3 (metabolism)
• Minichromosome Maintenance Complex Component 7 (metabolism)