Junctional Adhesion Molecule C

A junctional adhesion molecule subtype that is expressed at high levels in PLACENTA; BRAIN; KIDNEY; and PLATELETS. It serves a variety of functions such as mediating leukocyte-platelet interactions, regulating trans-epithelial migration of POLYMORPHONUCLEAR LEUKOCYTES, and acting as a counter receptor for ALPHAM INTEGRIN.

Also Known As:

Networked: 39 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Imhof, Beat A: 12 articles (04/2018 - 05/2005)
2.	Aurrand-Lions, Michel: 10 articles (04/2018 - 05/2005)
3.	Chavakis, Triantafyllos: 5 articles (10/2013 - 10/2005)
4.	Nourshargh, Sussan: 4 articles (10/2013 - 05/2005)
5.	Colom, Bartomeu: 3 articles (10/2013 - 10/2009)
6.	Bardin, Florence: 2 articles (04/2018 - 11/2012)
7.	Ko, Yoon Sook: 2 articles (11/2017 - 10/2017)
8.	Meda, Paolo: 2 articles (06/2011 - 10/2009)
9.	Voisin, Mathieu-Benoit: 2 articles (06/2011 - 10/2009)
10.	Woodfin, Abigail: 2 articles (06/2011 - 10/2009)

Related Diseases

1.	Acute Lung Injury 12/01/2018 - "Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4+ aged neutrophils."
2.	Sepsis (Septicemia) 12/01/2018 - "Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4+ aged neutrophils."
3.	Ovarian Neoplasms (Ovarian Cancer) 10/01/2013 - "Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer." 08/05/2020 - "Subsequent mechanism study revealed that circKIF4A acted as a competitive endogenous RNA (ceRNA) to promoted ovarian cancer progression by sponging miR-127 and upregulated the expression of Junctional adhesion molecule 3 (JAM3). "
4.	Coronary Artery Disease (Coronary Atherosclerosis) 08/01/2023 - "Plasma junctional adhesion molecule C levels are associated with the presence and severity of coronary artery disease." 01/01/2012 - "The aim of the present study was to investigate the role of platelet-derived junctional adhesion molecule-C (JAM-C) in adhesion and differentiation of human CD34(+) cells in vitro, as well as its association with platelet-derived P-selectin in patients with coronary artery disease. "
5.	Esophageal Achalasia (Megaesophagus) 10/01/2016 - "In this study, we reported that junctional adhesion molecule C (JAM-C) knockout mice on a C57/B6 background developed progressive megaesophagus from embryonic day (E) 15.5 onward with complete penetrance. "

Related Drugs and Biologics

1.	P-Selectin
2.	Competitive Endogenous RNA
3.	Proteins (Proteins, Gene)
4.	Claudin-5
5.	Claudin-4
6.	Claudins
7.	Hypoxia-Inducible Factor 1
8.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
9.	Leukocyte Common Antigens (CD45 Antigen)
10.	NF-kappa B (NF-kB)