Acid Sensing Ion Channels

A family of proton-gated sodium channels that are primarily expressed in neuronal tissue. They are AMILORIDE-sensitive and are implicated in the signaling of a variety of neurological stimuli, most notably that of pain in response to acidic conditions.

Also Known As:

ASIC Channel; Acid-Sensing Ion Channels; Channel, Acid-Sensing Ion; Channel, Proton-Gated Sodium; Ion Channel, Acid-Sensing; Proton Gated Sodium Channel; Proton Gated Sodium Channels; Sodium Channel, Proton-Gated; Sodium Channels, Proton-Gated; Acid Sensing Ion Channel; Acid-Sensing Ion Channel; Proton-Gated Sodium Channel; Proton-Gated Sodium Channels

Networked: 538 relevant articles (3 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Lingueglia, Eric: 21 articles (10/2022 - 05/2002)
2.	Xu, Tian-Le: 20 articles (01/2022 - 01/2007)
3.	Xiong, Zhi-Gang: 17 articles (11/2020 - 09/2004)
4.	Lazdunski, Michel: 13 articles (10/2012 - 05/2002)
5.	Chen, Chih-Cheng: 12 articles (01/2022 - 10/2007)
6.	Hu, Wang-Ping: 12 articles (01/2022 - 05/2012)
7.	Qiu, Chun-Yu: 12 articles (01/2022 - 05/2012)
8.	Chu, Xiang-Ping: 12 articles (01/2021 - 09/2004)
9.	Sluka, Kathleen A: 12 articles (01/2020 - 12/2003)
10.	Wemmie, John A: 11 articles (01/2017 - 12/2003)

Related Diseases

1.	Pain (Aches) 06/01/2008 - "Advances in molecular and transgenic approaches have helped to identify novel therapeutic targets for the treatment of pain from tissue and nerve damage such as acid-sensing ion channels, transient receptor potential and NaV channels. " 02/01/2015 - "This study shows that l-THP can exert an inhibitory effect on the functional activity of native acid-sensing ion channels (ASICs), which are believed to mediate pain caused by extracellular acidification. " 10/10/2007 - "Previous pharmacological and behavioral studies suggest that peripheral acid-sensing ion channels (ASICs) contribute to pain sensation, and the expression of ASIC subunits is elevated in the rat spinal dorsal horn (SDH) in an inflammatory pain model. " 09/28/2023 - "Acid-sensing ion channels (ASICs) in dorsal root ganglion (DRG) neurons play an important role in inflammatory pain. " 01/01/2023 - "Acid-sensing ion channels (ASICs) play an important role in pain associated with tissue acidification. "
2.	Acidosis 01/01/2021 - "Recent studies have demonstrated that activation of acid-sensing ion channel 1a (ASIC1a) by tissue acidosis plays an important role in the injury of cartilage in RA. " 09/04/2023 - "Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention." 01/01/2023 - "Cells monitor acidosis of their surroundings via pH-sensing channels, including the acid-sensing ion channels (ASICs). " 01/01/2023 - "Acid-sensing ion channel 1a (ASIC1a) is responsible for acidosis-related physiopathological processes. " 01/01/2022 - "We previously showed that activation of acid-sensing ion channel 1a (ASIC1a) by acidosis plays an important role in RA pathogenesis. "
3.	Osteoporosis 01/01/2017 - "Moreover, treatment with bisphosphonate significantly prevented the triggering of the regional osteoporosis and pain-like behaviors, and antagonists of the acid-sensing nociceptors, such as transient receptor potential channel vanilloid subfamily member 1 and acid-sensing ion channels, significantly improved the pain-like behaviors in the tail-suspended mice. "
4.	Ischemia 01/01/2017 - "Studies suggest that afferent sensitization after ischemia depends on interactions between purinergic (P2X and P2Y) receptors, transient receptor potential (TRP) channels, and acid sensing ion channels (ASICs) in individual populations of peripheral sensory neurons. " 07/01/2015 - "In this review, the authors discuss the GluA2-lacking AMPARs, acid-sensing ion channel 1a, melastatin-related transient receptor potential 2 (TRPM2), TRPM7 and store-operated Ca(2+) channels expressed in ischemia-vulnerable neurons, and focus on the studies using in vitro and in vivo models of transient ischemia that supports a significant role for these channels in inducing increases in the [Ca(2+)]c and/or [Zn(2+)]c and delayed neuronal death, and their potential as therapeutic targets. " 04/01/2005 - "Recent studies on neuroprotection in ischemia have demonstrated that the activation of neuronal acid-sensing ion channels type 1 (ASIC-1) can lead to neuronal death. " 09/01/2023 - "Acid-sensing ion channel 1a contributes to the prefrontal cortex ischemia-enhanced neuronal activities in the amygdala." 01/01/2023 - "Considering that limb ischemia/reperfusion (I/R) is a feature of PAD, we determined the characteristics of acid-sensing ion channel (ASIC) currents in muscle dorsal root ganglion (DRG) neurons under the conditions of hindlimb I/R and ischemia of PAD. "
5.	Inflammation (Inflammations) 12/01/2022 - "Our previous studies have demonstrated that acid-sensing ion channel 1a (ASIC1a) was highly expressed in RASFs, and acidic microenvironment of synovial fluid in patients with RA can activate ASIC1a to promote synovial inflammation, leading to the progression of RA. " 03/01/2015 - "Previous studies suggest that there might be close relationship between acid-sensing ion channels (ASICs) and inflammation, however, the exact role of ASICs in microglia during inflammation remains elusive. " 01/07/2009 - "Many studies have reported increased expression of acid-sensing ion channel 3 (ASIC3) in inflammation and enhanced ASIC3 channel activity with pro-inflammatory mediators. " 07/01/2021 - "Acid-sensing ion channel 1a (ASIC1a) is essential in the process of sensing acidification and triggering inflammation. " 01/01/2017 - "Acid-sensing ion channels (ASICs) ASIC3 expressed mainly in peripheral sensory neurons play an important role in pain perception and inflammation development. "

Related Drugs and Biologics

1.	Acids
2.	Transient Receptor Potential Channels
3.	Salicylates
4.	Diphosphonates (Bisphosphonates)
5.	Aspirin (Acetylsalicylic Acid)
6.	Protons (Proton)
7.	Cations
8.	Amiloride (Midamor)
9.	Calcium
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Tooth Movement Techniques
2.	Therapeutics
3.	Subcutaneous Injections
4.	Ischemic Postconditioning
5.	Acupuncture Points (Acupuncture Point)