Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention.

Abstract

Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca2+ ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca2+‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheumatoid arthritis. This review summarizes the role of ASIC1a in the modulation of apoptosis via various signaling pathways across different disease states to provide insights for future studies on the underlying mechanisms and development of therapeutic strategies.

• Authors: Zhenyu Zhang, Minnan Chen, Wenjing Zhan, Yuechun Chen, Tongtong Wang, Zhonghua Chen, Yifei Fu, Gang Zhao, Dong Mao, Jingjing Ruan, Feng-Lai Yuan
• Journal: Cell death discovery (Cell Death Discov) Vol. 9 Issue 1 Pg. 330 (Sep 04 2023) ISSN: 2058-7716 [Print] United States
• PMID: 37666823 (Publication Type: Journal Article, Review)
• Copyright: © 2023. Cell Death Differentiation Association (ADMC).