Immobilized Nucleic Acids

DNA or RNA bound to a substrate thereby having fixed positions.

Also Known As:

Immobilized DNA; Immobilized Oligonucleotides; Immobilized RNA; Acids, Immobilized Nucleic; DNA, Immobilized; Nucleic Acids, Immobilized; Oligonucleotides, Immobilized; RNA, Immobilized

Networked: 23 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - Immobilized Nucleic Acids: 23

Experts

1.	González-Díaz, César Antonio: 1 article (01/2020)
2.	Gómez-López, Modesto: 1 article (01/2020)
3.	Lara-Padilla, Eleazar: 1 article (01/2020)
4.	Miliar-García, Ángel: 1 article (01/2020)
5.	Pérez-Vielma, Nadia Mabel: 1 article (01/2020)
6.	Carlsson, Daniel O: 1 article (07/2016)
7.	Mihranyan, Albert: 1 article (07/2016)
8.	Xu, Changgang: 1 article (07/2016)
9.	Aramesh, M: 1 article (04/2015)
10.	Cervenka, J: 1 article (04/2015)

Related Diseases

1.	Human Influenza (Influenza) 06/02/2009 - "In this paper, we focus on the in vitro transcription reaction (IVT) of both a long and short strand of H5 influenza A RNA (1777 and 465 nt) on both free and immobilized DNA templates to study these phenomena. " 09/07/2013 - "The assay consists of an array of 5'-thiolated ssDNA oligonucleotides immobilized on the surface of a Ag nanorod substrate that serve as capture probes for the detection of synthetic RNA sequences coding for a genetic mutation in the influenza PB1-F2 protein. "
2.	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 06/01/2008 - "On the basis of the potential importance of immobilized DNA in cell culture and the well-defined characteristics of alkanethiol self-assembled monolayers (SAMs), the current study was designed to create multifunctional SAMs upon which cell adhesion and DNA immobilization can be independently modulated. " 10/01/2005 - "Immobilized DNA on preformed 11-mercaptoundecanoic acids (MUDA) self-assembled monolayers (SAMs) on a gold (111) surface was bound by a divalent cation bridges was imaged by atomic force microscopy (AFM). "
3.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/01/1999 - "Preparation of DNA-immobilized immunoadsorbent for treatment of systemic lupus erythematosus." 09/05/1996 - "Batch adsorption of anti-DNA antibody to the grafted PET fibers with and without DNA immobilized on their surface was conducted with serum obtained from systemic lupus erythematosus model mice. " 01/01/1994 - "To elucidate the nature of the observed changes in DNases activity in systemic lupus erythematosus, nucleus proteins of the cells were separated electrophoretically in acrylamide gradient with immobilized DNA. " 07/01/2016 - "Feasibility of using DNA-immobilized nanocellulose-based immunoadsorbent for systemic lupus erythematosus plasmapheresis." 01/01/1999 - "A new DNA-immobilized immunoadsorbent was prepared to remove the pathogenic anti-DNA antibody from the serum of systemic lupus erythematosus (SLE) patients. "
4.	Neoplasms (Cancer) 04/14/2015 - "The selective detection is based on complementary hybridization of a fluorescently-tagged circulating cancer oncomarker (a 21-mer nucleic acid) with covalently immobilized DNA on the surface of the membrane. " 01/15/1987 - "In addition, viral DNA has not been detected in the differentiated tumors using viral cRNA probes to DNA immobilized on filters. " 01/01/2022 - "In this system, target 1 (miRNA-21) first triggered duplex-specific nuclease (DSN)-assisted recycle amplification to generate numerous disulfide-linked DNA strands (DL), which could effectively capture DNA nanotube to immobilize methylene blue (MB) to produce remarkable electrochemical signals and achieve the ultrasensitive detection of miRNA-21 with a detection limit down to 32.6 aM. Furthermore, in the presence of target 2 (GSH), the electrochemical signal was significantly reduced by a thiol-disulfide bond exchange reaction on DL to release MB-immobilized DNA nanotubes away from the sensing interface, which enabled the sensitive analysis of GSH with a detection limit of 0.379 nM. Impressively, this strategy could achieve ultrasensitive detection of different types of biomarkers to prominently lessen false-positive responses from the current sensing methods toward a single biomarker or the same type of biomarker and remarkably heighten the accuracy and precision of early cancer diagnosis. "
5.	Rupture 01/01/2023 - "We present here "Rupture And Deliver" Tension Gauge Tethers (RAD-TGTs) in which flow cytometry is used to record the mechanical history of thousands of cells exerting forces on their surroundings via their propensity to rupture immobilized DNA duplex tension probes. " 11/01/2010 - "The antibody is able to bind two 5-methylcytidine bases of a surface-immobilized DNA strand, and retracting the cantilever results in a unique rupture signature reflecting the spacing between two tagged bases. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	RNA (Ribonucleic Acid)
3.	Proteins (Proteins, Gene)
4.	Immunosorbents
5.	Biomarkers (Surrogate Marker)
6.	Transcription Factors (Transcription Factor)
7.	Sepharose (Agarose)
8.	Collodion (Nitrocellulose)
9.	Antibodies
10.	Complementary RNA (cRNA)

Related Therapies and Procedures

1.	Plasmapheresis