Nasal Septal Perforation

An opening or hole in the NASAL SEPTUM that is caused by TRAUMA, injury, drug use, or pathological process.

Also Known As:

Nasal Septum Perforation; Nasal Septal Perforations; Nasal Septum Perforations; Perforation, Nasal Septal; Perforation, Nasal Septum; Perforations, Nasal Septal; Perforations, Nasal Septum; Septal Perforation, Nasal; Septal Perforations, Nasal; Septum Perforation, Nasal; Septum Perforations, Nasal

Networked: 158 relevant articles (9 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Diabetes Insipidus
2.	Cerebrospinal Fluid Rhinorrhea
3.	Colorectal Neoplasms (Colorectal Cancer)
4.	Breast Neoplasms (Breast Cancer)
5.	Neoplasms (Cancer)

Experts

1.	Çakan, Doğan: 2 articles (07/2022 - 10/2019)
2.	Hamilton, Grant S: 2 articles (07/2021 - 06/2015)
3.	Hong, Seung-No: 2 articles (07/2021 - 12/2016)
4.	Kridel, Russell W H: 2 articles (02/2020 - 11/2004)
5.	Pribitkin, Edmund A: 2 articles (06/2013 - 11/2003)
6.	Jatoi, Aminah: 2 articles (08/2012 - 05/2011)
7.	Ramiscal, Judi Anne B: 2 articles (08/2012 - 05/2011)
8.	Berggren, Diana: 2 articles (03/2012 - 01/2009)
9.	Hamilton, Stefan: 1 article (12/2022)
10.	Rotenberg, Brian W: 1 article (12/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nasal Septal Perforation:

1.	Biocompatible Materials (Biomaterials)IBA 07/01/2021 - "Previous studies have reported that biocompatible materials may be effective for repairing nasal septal perforations. " 07/01/2021 - "The purpose of the study was to develop a septal cartilage implant biomaterial for use in the reconstruction of nasal septal perforations and prepare personalized implants for each patient individually using 3D printing technology. " 07/01/2021 - "Biomaterials in the Reconstruction of Nasal Septum Perforation."
2.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 06/01/2006 - "The application of fibrin glue at the bilaterally injured mucosal surface after cartilage insertion is thought to be very useful as a preventive measure of nasal septal perforation. " 06/01/2006 - "We report these results as preliminary data for further study to determine the usefulness of fibrin glue in the prevention of nasal septal perforation."
3.	LactoferrinIBA 10/01/2023 - "The aim of the present experimental animal study was to investigate the efficacy of bovine lactoferrin (LF) on wound healing in an animal model of nasal septum perforation (NSP).Twenty-two, 8 to 10 weeks of age, male Sprague-Dawley rats were separated into two groups. " 10/01/2023 - "The Efficacy of Topical Lactoferrin on Wound Healing in an Experimental Animal Model of Nasal Septum Perforation."
4.	CollagenIBA 11/11/2021 - "Nasal septal perforations were repaired by the endoscopic sandwich technique with the collagen membrane and umbilical cord-derived mesenchymal stem cells. " 11/11/2021 - "We aimed to investigate the clinical efficacy of collagen membrane with umbilical cord-derived mesenchymal stem cells in the endoscopic repair of nasal septal perforation.Methods" 11/11/2021 - "Clinical application of collagen membrane with umbilical cord-derived mesenchymal stem cells to repair nasal septal perforation." 10/01/2013 - "Marine collagen scaffolds for nasal cartilage repair: prevention of nasal septal perforations in a new orthotopic rat model using tissue engineering techniques." 05/01/2019 - "Anterior ethmoidal artery flap with an inlay collagen matrix is a reliable technique to repair nasal septal perforation. "
5.	Collagen Type II (Type II Collagen)IBA 10/01/2013 - "Chondrocytes were able to adhere to marine collagen and produce cartilaginous matrix proteins, such as collagen type II. Treating septal cartilage defects in vivo with seeded and unseeded scaffolds led to a significant reduction in the number of nasal septum perforations compared to no replacement. "
6.	Proteins (Proteins, Gene)FDA Link 10/01/2013 - "Chondrocytes were able to adhere to marine collagen and produce cartilaginous matrix proteins, such as collagen type II. Treating septal cartilage defects in vivo with seeded and unseeded scaffolds led to a significant reduction in the number of nasal septum perforations compared to no replacement. "
7.	Polypropylenes (Polypropylene)IBA 11/30/2023 - "In this study, we aimed to investigate the effectiveness of the use of polypropylene mesh and platelet-rich fibrin (PRF) in nasal septal perforation (NSP) repair. " 01/01/2017 - "The aim of this study is to determine the effectiveness and biocompatibility of polypropylene mesh for the repair of nasal septal perforations in an animal model on rabbits. " 01/01/2017 - "Polypropylene mesh for nasal septal perforation repair: an experimental study." 11/30/2023 - "The Use of Platelet-Rich Fibrin and Polypropylene Mesh in Repair of Nasal Septal Perforation."
8.	Bevacizumab (Avastin)FDA Link 02/01/2021 - "The possibility of nasal septal perforation by bevacizumab was considered by excluding other causes. " 05/01/2017 - "Nasal septal perforation secondary to systemic bevacizumab." 08/01/2012 - "This discussion summarizes suggestions for management of bevacizumab-associated nasal septal perforation and, as relevant to healthcare providers, discusses some of the practical aspects of post-marketing pharmacovigilance." 08/01/2012 - "Nasal septal perforation from bevacizumab: a discussion of outcomes, management, and pharmacovigilance." 04/01/2011 - "[Nasal septum perforation and bevacizumab]."
9.	PlasticsIBA 01/01/2013 - "Based on the results of this study, the authors recommend to prescribe low-molecular weight heparins for prophylactic purposes to the patients undergoing plastic closure of nasal septum perforations. " 01/01/2013 - "The objective of the present study was to identify specific hematological features characterizing the pathophysological processes of clinical significance associated with plastic closure of nasal septum perforations. " 01/01/2021 - "[Nasal septum perforation non-surgical treatment and preparation for plastic closure: literature review and own experience]." 01/01/2016 - "[The application of the lyophilized xenodermoimplants for the plastic correction of the external auditory canal and nasal septum perforation]." 01/01/2013 - "[The phenomenon of vascular microthrombosis in mucoperichondrium associated with plastic closure of nasal septum perforations]."
10.	AllodermIBA 02/01/2003 - "In total, 17 patients with symptomatic anterior nasal septal perforations that had failed conservative treatment underwent a closed endoscopic repair of their perforations with acellular human dermal allograft (alloderm) and an anteriorly based inferior turbinate flap; 13 patients had a successful closure of the perforation, two patients, despite initial success, re-perforated as a result of persistent crust picking and, in two patients, the graft failed. " 05/01/2007 - "The aim of this study was to compare the compatibility of Alloderm, Dacron, Gore-Tex, and autologous cartilage graft materials with host tissues in nasal septal perforation repair surgery. "

Therapies and Procedures

1.	Rhinoplasty 12/01/2016 - "Concurrent rhinoplasty and nasal septal perforation repair is a safe and effective option when necessary. " 03/01/2019 - "1.) Describe demographic and clinical characteristics of pediatric nasal septal perforations (NSP), 2.) Analyze efficacy of treatment modalities in symptom management and resolution of pediatric NSP, 3.) Describe the surgical technique of external rhinoplasty with vascularized nasal septal flaps in the treatment of nasal septal perforations. " 08/01/2020 - "Combining rhinoplasty and nasal septal perforation repair in appropriately selected patients can be safely done with excellent results. " 02/01/2020 - "The rhinoplasty surgeon may encounter nasal septal perforations (NSPs) during the examination of the prospective rhinoplasty candidate, many of whom have had prior septal surgery. " 01/01/1997 - "The closure of nasal septal perforations via external rhinoplasty approach has a high percentage of success due to excellent exposure of the septum."
2.	Prostheses and Implants (Prosthesis) 01/01/2009 - "Questionnaire and retrospective chart review were used to evaluate the efficacy of this prosthesis as treatment of disturbing symptoms from nasal septal perforation. " 12/01/2022 - "Nasal septal perforations can be managed with a septal button prosthesis. " 01/01/2021 - "Quality-of-life changes following three-dimensional printing of prosthesis for large nasal septal perforations-Our experience of 13 patients." 02/01/2013 - "Two-piece nasal septum prosthesis for a large nasal septum perforation: a clinical report." 01/01/2009 - "Treatment of nasal septal perforations with a custom-made prosthesis."
3.	Conservative Treatment 06/26/2023 - "Nasal septal perforation (NSP) repair is challenging surgery considered in patients with symptomatic NSP intractable to conservative treatments. " 04/07/2022 - "Therefore, if nasal septal perforation does not improve with appropriate conservative treatment, clinicians should consider a malignant disease such as extranodal nasal-type NKTL." 01/01/2021 - "This article presents a short review of publications and our own clinical examples of nasal septum perforation conservative treatment methods in children and adults. " 06/01/2001 - "Complications were follows: cerebrospinal fluid rhinorrhea in 2 cases, diabetes insipidus in 1 case, all of them were cured by conservative treatment; nasal septum perforation in 1 case, without any treatment. " 02/01/2003 - "In total, 17 patients with symptomatic anterior nasal septal perforations that had failed conservative treatment underwent a closed endoscopic repair of their perforations with acellular human dermal allograft (alloderm) and an anteriorly based inferior turbinate flap; 13 patients had a successful closure of the perforation, two patients, despite initial success, re-perforated as a result of persistent crust picking and, in two patients, the graft failed. "
4.	Stents 08/01/2016 - "An attempt has been made in the present report to address the prosthetic management of pateint having nasal septum perforation utilizing a unilateral, custom made heat cured acrylic stent and the details of the technique are presented. "
5.	Surgical Flaps 06/01/2021 - "Greater palatine artery pedicled flap for nasal septal perforation repair: radiological study and case series." 05/01/2015 - "Nasal septal perforation reconstruction with superior-based pedicled nasolabial island flap in a patient with the Raynaud phenomenon."