The aim of this study is to determine the effectiveness and biocompatibility of
polypropylene mesh for the repair of
nasal septal perforations in an animal model on rabbits. A full-thickness
nasal septal perforation with a diameter of nearly 10 × 10 mm was created on 12 rabbits, and then the perforation was reconstructed with two different methods. We used mucosal flaps and
polypropylene mesh as an interpositional graft in group 1. Only mucosal flaps were used for reconstruction and are identified as group 2. After 4 weeks, we removed the nasal septum of the rabbits and performed histopathological examinations for acute rejection,
infection, inflammatory response,
fibrosis, and
granuloma formation. We found perforation closure rates of 75 and 25 % in groups 1 and 2, respectively. Inflammatory response was seen in all specimens of group 1 (100 %). The inflammatory response was +1 in five of the specimens (62.5 %), +2 in one specimen (12.5 %), and +3 in two specimens (25 %). Mild
fibrosis around the mesh was detected in four specimens (50 %), medium-level
fibrosis was detected in one (12.5 %), and no
fibrosis was detected in three (37.5 %). Severe
fibrosis was not seen in any specimens. The
foreign-body reaction was limited to a few giant cells, and
granuloma formation was seen in two specimens (25 %). The
propylene mesh showed excellent biocompatibility with the septal mucosa, and it can, therefore, be used for the repair of septal perforation as an interpositional graft safely.