Polyketides

Natural compounds containing alternating carbonyl and methylene groups (beta-polyketones), bioenergenetically derived from repeated condensation of acetyl coenzyme A via malonyl coenzyme A, in a process similar to fatty acid synthesis.

Also Known As:

Networked: 231 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Khosla, Chaitan: 5 articles (01/2021 - 11/2004)
2.	Marsollier, Laurent: 5 articles (01/2019 - 08/2008)
3.	Cole, Stewart T: 5 articles (01/2018 - 02/2007)
4.	Stinear, Timothy P: 5 articles (06/2012 - 12/2003)
5.	Watanabe, Kenji: 4 articles (01/2022 - 07/2009)
6.	Shen, Ben: 4 articles (12/2017 - 02/2009)
7.	Jenkin, Grant A: 4 articles (11/2009 - 12/2003)
8.	Ju, Jianhua: 3 articles (11/2021 - 02/2009)
9.	Müller, Rolf: 3 articles (01/2021 - 06/2012)
10.	Oswald, Eric: 3 articles (01/2020 - 12/2008)

Related Diseases

1.	Pneumonia (Pneumonitis) 05/01/2021 - "The macrocyclic polyketide compounds exhibited wide-spectrum of anti-infective potential against clinically significant vancomycin-resistant Enterococcus faecalis (VREfs), methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and Klebsiella pneumonia with minimum inhibitory concentration of about 1-3 µg ml-1 , insomuch as the antibiotics chloramphenicol and ampicillin were active at ≥6·25 µg ml-1 . "
2.	Neoplasms (Cancer) 07/21/2014 - "These studies demonstrate that a rare class of Streptomyces polyketide modulates K-Ras plasma membrane localisation, with implications for the future treatment of K-Ras dependent cancers. " 08/01/2013 - "As a continuation of our ongoing studies aimed to depict the effects and mechanism of action of naturally occurring oxyprenylated phenylpropanoids and polyketides, in this paper we describe the synthesis and in vitro anti-proliferative effects of selected compounds belonging to the above cited classes of secondary metabolites on six cancer cell lines using the MTT colorimetric assay. " 01/01/2022 - "Polyketides isolated from an endophyte Penicillium oxalicum 2021CDF-3 inhibit pancreatic tumor growth." 05/06/2021 - "The cytotoxic activity of all isolated polyketides 1-7 was evaluated, and compounds 2, 6, and 7 exhibited potent activities against A549, HepG2, and MDA-MB-231 human cancer cell lines with IC50 value ranging from 1.86 to 18.31 μM. " 01/01/2019 - "Diaphorin, a polyketide produced by a bacterial symbiont of the Asian citrus psyllid, kills various human cancer cells."
3.	Dehydration (Water Stress) 12/01/2017 - "In contrast to canonical DHs that catalyze dehydration of the β-hydroxy groups of the nascent polyketide intermediates, DH10 acts in a long-range manner that is unprecedented for type I PKSs, a novel dehydration mechanism that could be exploited for polyketide structural diversity by combinatorial biosynthesis and synthetic biology." 08/01/2019 - "The dehydratase (DH) domain within modular type I PKSs generates an α,β-unsaturated bond in nascent polyketide intermediates through a dehydration reaction. " 01/01/2018 - "The biosynthesis of bacterial DHN utilized a type III PKS for polyketide synthesis, an AKR superfamily for reduction, and a SnoaL2-like NTF2 superfamily for dehydration, whereas the biosynthesis of fungal DHN utilized a type I PKS, SDR superfamily enzyme, and SD-like NTF2 superfamily. " 01/01/2017 - "Dehydration reactions play a crucial role in the de novo biosynthesis of fatty acids and a wide range of pharmacologically active polyketide natural products with strong emphasis on human medicine. " 12/14/2016 - "The curacin pathway houses a rare plurality of possible double bond permutations containing conjugated olefins as well as both cis- and trans-olefins, providing an unrivaled model system for polyketide dehydration. "
4.	Buruli Ulcer 12/18/2001 - "Mycolactones are polyketide toxins produced by Mycobacterium ulcerans, the causative agent of the tropical skin disease known as Buruli ulcer. " 01/01/2022 - "Here, we describe an ELISA protocol suitable for the detection of mycolactone, the polyketide toxin of Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU). " 01/01/2017 - "Mycolactone, a polyketide molecule produced by Mycobacterium ulcerans, is the etiological agent of Buruli ulcer. " 01/01/2016 - "Mycolactone is a polyketide toxin secreted by the mycobacterium Mycobacterium ulcerans, responsible for the extensive hypoalgesic skin lesions characteristic of patients with Buruli ulcer. " 08/01/2008 - "Mycobacterium ulcerans is the causative agent of Buruli ulcer, a rapidly emerging human disease in which mycolactone, a cytotoxic and immunosuppressive macrocyclic polyketide, is responsible for massive skin destruction. "
5.	Starvation 10/01/2016 - "Here, we elucidate the structure of a hybrid polyketide-nonribosomal peptide from Caenorhabditis elegans that is produced in the canal-associated neurons (CANs) and promotes survival during starvation-induced larval arrest. " 01/01/2017 - "Biakamides A-D, Unique Polyketides from a Marine Sponge, Act as Selective Growth Inhibitors of Tumor Cells Adapted to Nutrient Starvation." 05/01/1999 - "Physiological studies have shown that Streptomyces rimosus produces the polyketide antibiotic oxytetracycline abundantly when its mycelial growth is limited by phosphate starvation. " 01/01/2018 - "BPS: bathophenanthrolinedisulfonate; BSA: bovine serum albumin; CFU: colony forming unit; -Fe: iron starvation; +Fe: iron sufficiency; hFe: high iron; NRPSs: nonribosomal peptide synthetases; PKSs: polyketide synthaseses; wt: wild type." 07/23/2021 - "Gene ontology (GO)-term enrichment and KEGG analysis of the genes regulated by P starvation and P replenishment revealed that metabolism is an important component of the P starvation response that is aimed at P homeostasis, with large changes occurring in glyco-and galactolipid and carbohydrate metabolism, biosynthesis of secondary metabolites, including terpenoids and polyketides, glycan biosynthesis and metabolism, and amino acid metabolism. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Vancomycin
3.	Chloramphenicol (Chloromycetin)
4.	Ampicillin (Omnipen)
5.	Peptides (Polypeptides)
6.	Macrolides
7.	mycolactone A
8.	Enzymes
9.	Fatty Acids (Saturated Fatty Acids)
10.	glutarimide

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Photochemotherapy (Photodynamic Therapy)