colibactin

12/16/2020 - "Recent studies have provided strong evidence supporting the causative role of colibactin in human colorectal cancer (CRC) progression. "
01/01/2020 - "Our study describes a distinct mutational signature in colorectal cancer and implies that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island."
01/01/2019 - "coli strains from Japanese colorectal cancer patients, and in the present study we investigated the genotoxic potency of the colibactin-producing (clb+) E. "
10/20/2017 - "The presence of colibactin metabolites has been correlated to colorectal cancer formation in several studies. "
10/05/2023 - "This report shows that colibactin may influence development of colorectal neoplasms in predisposed patients."

01/01/2022 - "The colibactin cluster was discovered more than 15 years ago, and most of the research studies have been focused on revealing the biosynthesis and precise structure of the cryptic encoded molecule(s) and the mechanism of carcinogenesis. "
01/01/2019 - "While high-colibactin-producing Escherichia coli is thought to be associated with colorectal oncogenesis, this study is complicated part due to an inability to isolate colibactin adequately. "
01/01/2016 - "Herein, we discuss both human data from meta'omics analyses and data from mechanistic studies in cell culture and animal models that support specific bacterial agents as potentiators of tumorigenesis-including Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, and colibactin-producing Escherichia coli. "
12/01/2021 - "coli harboring this biosynthetic gene cluster cause DNA damage and tumorigenesis in cell lines and pre-clinical models, yet fundamental knowledge regarding colibactin function is lacking. "
01/01/2021 - "coli and the molecular mechanism of oncogenesis by colibactin may provide us with opportunities for early diagnosis or prevention of colorectal oncogenesis. "

01/01/2020 - "The present study provides evidence for the etiological role of colibactin in human cancer."
10/05/2023 - "Colibactin mutational signatures in NTHL1 tumor syndrome and MUTYH associated polyposis patients."
12/01/2022 - "Colibactin: beyond DNA damage and cancer."
12/01/2021 - "coli in cancer etiology, the biological mechanisms governing production and delivery of colibactin by these bacteria must be elucidated. "
11/08/2021 - "Mechanistic dissection unmasks colibactin as a prevalent mutagenic driver of cancer."

01/01/2022 - "In this study, we abolished the clbA gene in the APEC XM strain, investigated the effect of clbA on colibactin synthesis and evaluated the pathogenic capacity of colibactin on meningitis development. "
01/01/2022 - "We conclude that ClbA is obligatory for the synthesis of colibactin and is responsible for the development of meningitis in mice infected by APEC."
12/01/2021 - "These results indicate that clbH is a necessary component for the synthesis of genotoxic colibactin, and colibactin is related to the development of meningitis induced by APEC XM."
12/01/2021 - "Colibactin in avian pathogenic Escherichia coli contributes to the development of meningitis in a mouse model."
01/01/2018 - "coli urosepsis and meningitis in immunocompromised mice, and highlights the importance of monitoring and exclusion of colibactin-producing pks+ E. "

03/01/2021 - "To investigate the biological activity of Thai medicinal plant extracts and their active substances on the inhibition of growth and the transcription of colibactin genes of colibactin-producing Escherichia coli, and effect on the pathogenesis from colibactin toxin including transient infections and colibactin-induced DNA damage. "
03/01/2021 - "Medicinal plant extracts protect epithelial cells from infection and DNA damage caused by colibactin-producing Escherichia coli, and inhibit the growth of bacteria."
01/01/2021 - "In a murine model of UTI, the machinery producing colibactin was expressed during the early hours of the infection, when intracellular bacterial communities form. "
01/01/2020 - "Our data show that colibactin, beyond targeting the host, may also exert its genotoxic effect on the gut microbiota.IMPORTANCE Infections of genotoxic Escherichia coli spread concomitantly with urbanized progression. "
03/20/2018 - "Here we describe a method to quantify the genotoxicity of bacteria producing colibactin following a short infection of cultured mammalian cells with colibactin producing E. "