alpha-2-HS-Glycoprotein

A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD.

Also Known As:

AHSG Protein; Fetuin-A; alpha(2) HS Glycoprotein; alpha-2HS Glycoprotein; alpha2HS Glycoprotein; Fetuin A; alpha 2 HS Glycoprotein; alpha 2HS Glycoprotein; alpha2 Heremans-Schmid Glycoprotein

Networked: 886 relevant articles (22 outcomes, 239 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jahnen-Dechent, Willi: 24 articles (01/2022 - 03/2003)
2.	Ix, Joachim H: 24 articles (12/2020 - 04/2006)
3.	Stefan, Norbert: 19 articles (01/2022 - 04/2006)
4.	Ketteler, Markus: 18 articles (01/2017 - 03/2003)
5.	Ochieng, Josiah: 15 articles (04/2022 - 12/2003)
6.	Häring, Hans-Ulrich: 15 articles (01/2021 - 04/2006)
7.	Fritsche, Andreas: 12 articles (01/2018 - 04/2006)
8.	Emoto, Masanori: 11 articles (01/2021 - 02/2006)
9.	Inaba, Masaaki: 11 articles (01/2021 - 02/2006)
10.	Mori, Katsuhito: 11 articles (01/2021 - 02/2006)

Related Diseases

1.	Inflammation (Inflammations) 02/01/2022 - "Our study concluded that salivary and serum fetuin-A levels diminished with increasing severity of periodontal inflammation, and NSPT remarkably improved their levels. " 12/01/2020 - "Blood samples were studied for calcification and inflammation markers and fetuin-A was checked 3 times at the start, middle and the end of the study. " 04/01/2011 - "In this study, relationship between coronary artery calcification, inflammation, and serum fetuin-A levels were investigated. " 01/01/2022 - "Thus, fetuin-A plays a suppressive role in inflammation. " 01/01/2022 - "We report here that in wild-type mice 12 days after Chlamydia muridarum (Cm) intranasal challenge, fetuin-A content in the lungs decreased 46%, while INF-γ increased 44%, consistent with a negative regulatory role of fetuin-A in inflammation. "
2.	Insulin Resistance 10/26/2021 - "Decreased circulating levels of fetuin-A improved lipid metabolism and attenuated insulin resistance in the liver and in peripheral tissues. " 10/25/2022 - "In conclusion, this study demonstrated liver fetuin-A overexpression at the initiation of high-fat diet feeding, concurrent with hepatic steatosis and insulin resistance. " 03/27/2018 - "This study aims to investigate the correlation between monocyte subsets with fetuin-A and its relevant insulin resistance. " 01/01/2018 - "In conclusion, although there is mechanistic evidence for an effect of fetuin-A on insulin sensitivity and secretion, this study does not support a strong, relevant relationship between circulating fetuin-A and diabetes risk in the general population." 10/01/2017 - "This study aims to determine the relationship between fetuin-A levels and cardiometabolic risk factors, as well as to investigate the effect of serum fetuin-A on insulin resistance indices to determine whether fetuin-A is an additional marker for insulin resistance in prepubertal children. "
3.	Vascular Calcification 07/31/2022 - "Results showed that compared with the control group, the expression of mir-29a-5p and sclerostin in the study group was higher, and the expression of fetuin-A was lower, the difference was statistically significant (P < 0.05); The expression of mir-29a-5p, sclerostin and fetuin-A in calcified group was higher than that in non-calcified group, and the expression of fetuin-A was lower (P < 0.05); Mir-29a-5p and sclerostin showed positive correlation (r=6.776, P=0.011); The expression of mir-29a-5p and fetuin-A showed negative correlation (r=-5.326, P=0.001); The expression of mir-29a-5p and sclerostin showed negative correlation (r=-9.677, P=0.001); Mir-29a-5p and sclerostin were positively correlated with vascular calcification (r=0.695, P=0.001; r=0.715, P=0.001), and fetuin-A was positively correlated with vascular calcification (r = -0.953, P = 0.001). " 12/01/2017 - "The main purpose of this study was evaluating the correlation between fetuin-A and PTX3 with some biochemical parameters effective upon vascular calcification in HD patients. " 01/01/2016 - "Large controlled studies are needed to establish the role of fetuin-A in vascular calcification in Indian population. " 05/01/2011 - "This study investigated the relationships between fetuin-A, vascular calcification, and outcome in such patients. " 01/01/2008 - "Among these mediators, studies on fetuin-A deserve further attention as clinical studies consistently show that fetuin-A deficiency is associated with vascular calcification, all-cause and cardiovascular mortality in CKD patients. "
4.	Sepsis (Septicemia) 01/01/2019 - "Comment to: Are fetuin-A levels beneficial for estimating timing of sepsis occurrence?" 07/01/2018 - "Are Fetuin-A levels beneficial for estimating timing of sepsis occurrence?" 07/01/2018 - "To evaluated Fetuin-A levels of patients admitted in the intensive care unit with a diagnosis of sepsis. Methods: This study was conducted at the Faculty of Medicine, Çanakkale Onsekiz Mart University Hospital, Çanakkal, Turkey, between February 2015 and October 2015. " 11/30/2022 - "It was to investigate the predictive value of NGAL and Fetuin-A for 28-day mortality in patients with sepsis, and to construct a mortality risk prediction model. " 11/30/2022 - "Combined Serum NGAL and Fetuin A to Predict 28-Day Mortality in Patients with Sepsis and Risk Prediction Model Construction."
5.	Atherosclerosis 01/01/2017 - "Fetuin-A and Risk of Diabetes Independent of Liver Fat Content: The Multi-Ethnic Study of Atherosclerosis." 05/01/2016 - "We conducted a case-cohort study of fetuin-A and incident non-fatal CVD nested in the Multi-Ethnic Study of Atherosclerosis with follow-up from 2000 to 2007. " 01/01/2016 - "Since the role of fetuin-A in atherosclerosis remains still controversial, we aimed to clarify it in this study. " 07/01/2012 - "Although our study shows that serum PTX3 is increased and Fetuin-A is decreased after successful RT, their direct role on atherosclerosis needs further studies in the future." 05/01/2012 - "Fetuin-A is inversely associated with coronary artery calcification in community-living persons: the Multi-Ethnic Study of Atherosclerosis."

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Sirtuin 1
3.	Insulin (Novolin)
4.	Interleukin-6 (Interleukin 6)
5.	Glucose (Dextrose)
6.	Enzymes
7.	Immunosorbents
8.	Peptides (Polypeptides)
9.	HMGB1 Protein (HMG1)
10.	Collagen

Related Therapies and Procedures

1.	Percutaneous Coronary Intervention
2.	Caloric Restriction
3.	Renal Dialysis (Hemodialysis)
4.	Therapeutics
5.	Glycemic Control