Serum Fetuin-A and Pentraxin3 in hemodialysis and renal transplant patients.

Abstract

OBJECTIVE:

The aim of the present study was to evaluate of Fetuin-A and Pentraxin3 (PTX3) as the main factors for vascular calcification and inflammation in hemodialysis (HD) and renal transplant (RT) patients.

METHOD:

Serum was obtained from 45 stable chronic HD patients and 44 stable RT recipients. Biochemical factors, intact Parathormone, high-sensitive C-reactive protein (hsCRP), Fetuin-A and PTX3 levels were determined by standard methods.

RESULTS:

In the RT recipients PTX3 level was significantly higher than the HD patients [5.78(1.09-20.36) ng/mL vs. 1.65(0.24-7.89) ng/mL, p ≤ 0.001]. Serum Fetuin-A concentration was significantly higher in the HD compared to RT group [43.39(27.75-81.48) ng/mL vs. 38.76(22.26-89.07) ng/mL, p=0.020]. hsCRP level was also higher in the HD than the RT group [2.90(0.1-8.50) mg/L vs. 1.1(0.1-7.9) mg/L, p=0.003].

CONCLUSION:

Although our study shows that serum PTX3 is increased and Fetuin-A is decreased after successful RT, their direct role on atherosclerosis needs further studies in the future.

• Authors: Hassan Argani, Amir Ghorbanihaghjo, Ghodratollah Panahi, Nadereh Rashtchizadeh, Javid Safa, Saeed Mahmoudi Meimand
• Journal: Clinical biochemistry (Clin Biochem) Vol. 45 Issue 10-11 Pg. 775-9 (Jul 2012) ISSN: 1873-2933 [Electronic] United States
• PMID: 22546644 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Chemical References

• Serum Amyloid P-Component
• alpha-2-HS-Glycoprotein
• PTX3 protein
• C-Reactive Protein

Topics

• Adult
• C-Reactive Protein (metabolism)
• Female
• Humans
• Kidney Failure, Chronic (blood, therapy)
• Kidney Transplantation (methods)
• Male
• Middle Aged
• Renal Dialysis
• Serum Amyloid P-Component (metabolism)
• alpha-2-HS-Glycoprotein (metabolism)