A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.
Also Known As:
CD95 Antigen; Fas Cell Surface Death Receptor; TNFRSF6 Receptor; fas Antigen; APO 1 Antigen; Receptor, TNFRSF6; Receptor, fas; APO-1 Antigen; Antigens, CD95; CD95 Antigens; Receptors, fas; Tumor Necrosis Factor Receptor Superfamily, Member 6; fas Antigens; fas Receptors