Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma.

Abstract

We studied whether Fas-receptor (Fas-R; CD95) expression, single-nucleotide polymorphisms (SNPs) in the Fas promoter region, and/or Fas-ligand (Fas-L) production could determine individual susceptibility to cervical cancer progression. The clinicopathologic features of 38 patients with cervical squamous carcinomas (22 stage I, 8 stage II, and 8 stage III+) were reviewed and related with: (a) Fas-R expression by immunohistochemistry; (b) Fas-R SNPs at -670 and -1377 locations by restriction fragment length polymorphism and DNA sequencing; and (c) Fas-L expression by immunohistochemistry. Overall and disease-free survival curves showed significant differences in relation to stage (p < 0.001). Fas-R was identified in 20 of 38 (52.6%) tumors without statistical differences in survival, stage, or Fas-L overproduction. Fas-R GG genotype was more common than expected in advanced tumors (p = 0.065). The Fas-R-1377A allele and AA genotype were unrelated with survival, stage, or Fas-R expression. Fas-L overproduction was detected in 20 of 38 (52.6%) tumors; it was more frequent in advanced-stage tumors and was inversely related to survival (p = 0.03) and decrease in host inflammatory response (p = 0.01). Fas-R expression by tumor cells seems unrelated to stage or lymphoid infiltrate. Tumor production of Fas-L may represent an attempt to destroy the host's lymphocytic reaction.

• Authors: Enrique Lerma, Marisa Romero, Alberto Gallardo, Cristina Pons, Josefina Muñoz, Josefina Fuentes, Belen Lloveras, Lluis Catasus, Jaime Prat
• Journal: Virchows Archiv : an international journal of pathology (Virchows Arch) Vol. 452 Issue 1 Pg. 65-74 (Jan 2008) ISSN: 0945-6317 [Print] Germany
• PMID: 18000680 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• DNA Probes, HPV
• DNA, Viral
• Fas Ligand Protein
• fas Receptor

Topics

• Adult
• Aged
• Biomarkers, Tumor (metabolism)
• Carcinoma, Squamous Cell (metabolism, mortality, secondary, virology)
• DNA Probes, HPV
• DNA, Viral (isolation & purification)
• Disease-Free Survival
• Fas Ligand Protein (metabolism)
• Female
• Humans
• Immunohistochemistry
• Middle Aged
• Neoplasm Staging
• Survival Rate
• Uterine Cervical Neoplasms (metabolism, mortality, pathology, virology)
• fas Receptor (metabolism)