Angiodysplasia

Acquired degenerative dilation or expansion (ectasia) of normal BLOOD VESSELS, often associated with aging. They are isolated, tortuous, thin-walled vessels and sources of bleeding. They occur most often in mucosal capillaries of the GASTROINTESTINAL TRACT leading to GASTROINTESTINAL HEMORRHAGE and ANEMIA.

Also Known As:

Networked: 539 relevant articles (52 outcomes, 40 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	von Willebrand Diseases (von Willebrand's Disease)
3.	Gastrointestinal Hemorrhage (Hematochezia)
4.	Vascular Malformations
5.	Gastric Antral Vascular Ectasia (Watermelon Stomach)

Experts

1.	McNamara, Deirdre: 6 articles (11/2021 - 10/2010)
2.	Holleran, Grainne: 5 articles (11/2021 - 04/2013)
3.	Dan, V N: 4 articles (01/2015 - 01/2007)
4.	Sapelkin, S V: 4 articles (01/2015 - 01/2007)
5.	Almeida, Nuno: 3 articles (02/2022 - 04/2009)
6.	Bartoli, Carlo R: 3 articles (03/2021 - 09/2017)
7.	Hennessy-Strahs, Samson: 3 articles (03/2021 - 09/2017)
8.	Drenth, J P H: 3 articles (10/2019 - 09/2006)
9.	Blackshear, Joseph L: 3 articles (01/2019 - 01/2016)
10.	Hall, Barry: 3 articles (02/2016 - 04/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Angiodysplasia:

1.	Octreotide (Sandostatin)FDA LinkGeneric 01/01/2008 - "Although octreotide treatment seems to be beneficial in reducing the blood loss from angiodysplasias, controlled studies to determine its optimal use are awaited. " 02/01/2007 - "This study suggests that octreotide treatment may be beneficial in preventing rebleeding from gastrointestinal angiodysplasia." 09/15/2007 - "Octreotide has shown to be effective against rebleeding from gastrointestinal angiodysplasias, but a long-term daily parenteral administration is recommended. " 05/01/2001 - "Long-acting octreotide is effective in controlling rebleeding angiodysplasia of the gastrointestinal tract." 08/17/2011 - "The authors conclude that octreotide is safe and effective in gastrointestinal angiodysplasias inaccessible to endoscopy or surgery."
2.	Thalidomide (Thalomid)FDA Link 12/01/2014 - "Thalidomide is effective in the treatment of angiodysplasia. " 06/01/2012 - "Thalidomide was reported to be effective in the treatment of angiodysplasia, but the mechanisms underlying its activity are, as yet, unknown. " 07/01/2015 - "The aim of this study was to present a new case on the successful use of thalidomide in a patient with acquired von Willebrand syndrome and recurrent angiodysplasia-related GI bleedings, and to conduct a literature review on the use of thalidomide in patients with GI angiodysplasia. " 12/01/2014 - "The aim of this study was to explore the expression and effects of Robo1 and Slit2 in angiodysplasia and to identify the possible therapeutic mechanisms of thalidomide. " 12/01/2019 - "Thalidomide is often used for the management of refractory gastrointestinal angiodysplasia (GIAD). "
3.	Estrogens (Estrogen)FDA Link 03/21/2016 - "For more than 50 years bleeding from gastrointestinal angiodysplasias has been treated by hormonal therapy with estrogens and progesterons. " 05/01/1987 - "Septal dermoplasty and oral estrogens may allow prolonged remission of epistaxis, but permanent surgical cure of gastrointestinal bleeding is rarely feasible because of diffuse angiodysplasia of the alimentary tract. " 01/01/2005 - "Judicious usage of estrogen/progesterone for angiodysplasia." 11/01/2001 - "Continuous estrogen-progestagen treatment is not useful in the prevention of rebleeding from gastrointestinal angiodysplasia." 11/01/2001 - "We investigated the efficacy of long-term estrogen-progestagen therapy in the prevention of rebleeding from gastrointestinal angiodysplasia. "
4.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 02/01/2016 - "Long-acting somatostatin analogues provide significant beneficial effect in patients with refractory small bowel angiodysplasia: Results from a proof of concept open label mono-centre trial." 11/01/2021 - "Effectiveness and predictors of response to somatostatin analogues in patients with gastrointestinal angiodysplasias: a systematic review and individual patient data meta-analysis." 02/01/2016 - "Long-acting somatostatin analogues offer a therapeutic advantage in a significant proportion of patients with small bowel angiodysplasia. " 11/01/2021 - "We excluded studies without original patient data, single case reports, small case series (ie, <10 participants), studies in which patients had a specific aetiology of gastrointestinal angiodysplasias, and studies in which somatostatin analogue therapy was initiated simultaneously with other treatment modalities. " 11/01/2021 - "All published randomised controlled trials and cohort studies that reported on somatostatin analogue therapy in patients with gastrointestinal angiodysplasias were eligible for screening. "
5.	von Willebrand FactorIBA 10/01/2023 - "As von Willebrand factor passes through a stenosed aorta, it is broken down and can no longer inhibit angiogenesis, leading to angiodysplasias. " 07/15/2023 - "A pathological examination revealed angiodysplasia, and the patient's plasma lacked high-molecular-weight von Willebrand factor (VWF) multimers, leading to the diagnosis of Heyde's syndrome. " 01/01/2022 - "Heyde's syndrome is characterized by AS, acquired deficiency or dysfunction of von Willebrand factor, and gastrointestinal angiodysplasia; however, the exact diagnostic criteria have not been established. " 01/01/2019 - "Since then, a link with intestinal angiodysplasia and abnormalities of von Willebrand factor (VWF) has been noted. " 08/01/2015 - "Could a Transient Deficiency in Von Willebrand Factor Be a Cause of Gastrointestinal Angiodysplasia?"
6.	ArgonIBA 07/01/2010 - "Endoscopic argon plasma ablation therapy is a new, effective and safe treatment in the management of gastrointestinal angiodysplasia. " 10/01/2015 - "to evaluate the efficiency of argon plasma electrocoagulation in the treatment of gastrointestinal angiodysplasia and to identify predictive factors of success of this technique. " 10/01/2007 - "[Duodenal angiodysplasia perforation after argon plasma therapy; solved with endoclips]." 03/26/1999 - "Argon-plasma laser coagulation (APC) for the angiodysplasia was performed twice. " 12/01/2003 - "Another patient with evidence of angiodysplasia and bleeding was effectively treated with Argon-beam during enteroscopy. "
7.	Progestins (Progestagens)IBA 11/01/2001 - "Continuous estrogen-progestagen treatment is not useful in the prevention of rebleeding from gastrointestinal angiodysplasia." 11/01/2001 - "We investigated the efficacy of long-term estrogen-progestagen therapy in the prevention of rebleeding from gastrointestinal angiodysplasia. " 02/01/1995 - "The efficacy of an association of estrogens and progestagens in the treatment of gastrointestinal bleeding by angiodysplasia was analyzed. " 02/01/1995 - "In conclusion, the combined treatment with estrogens and progestagens prevents recurrence of gastrointestinal bleeding by angiodysplasia." 11/01/1994 - "It has been suggested that estrogen-progestagen therapy may be useful in preventing bleeding from gastric angiodysplasia, a vascular lesion similar to that described in portal-hypertensive gastropathy. "
8.	ProgesteroneFDA LinkGeneric 07/01/1993 - "Oestrogen-progesterone may be a valuable alternative therapy in elderly patients with repeated bleeding, despite endoscopic coagulation, secondary to gastrointestinal angiodysplasia which cannot be treated surgically, in patients who deny surgery, or with rebleeding after surgery." 07/01/1993 - "A 75-year-old man with angiodysplasia of the sigmoid and rectum and recurrent lower gastrointestinal bleeding episodes, despite repeated endoscopic laser-coagulation, was successfully treated with oestrogen-progesterone. " 01/01/2005 - "Judicious usage of estrogen/progesterone for angiodysplasia." 01/29/2000 - "[Severe gastrointestinal hemorrhage secondary to diffuse angiodysplasia: efficacy of estrogen-progesterone treatment]." 07/01/1994 - "Von Willebrand's disease, digestive angiodysplasia, and estrogen-progesterone treatment."
9.	lanreotide (Somatuline)FDA Link 12/01/2018 - "Long-term results with lanreotide in patients with recurrent gastrointestinal angiodysplasias bleeding or obscure gastrointestinal bleeding. " 03/01/2016 - "[Efficacy of lanreotide in patients with gastrointestinal angiodysplasia refractory to octreotide therapy]." 08/01/2010 - "In 15 out of 46 patients with angiodysplasias IDA spontaneously resolved without any treatment; 9 patients required iron supplementation; 10 patients healed after lanreotide administration; APC was performed in 9 out of 46 patients and 3 patients underwent regular blood transfusion without any success on IDA. " 11/01/2021 - "Somatostatin analogue therapy is more effective in patients with angiodysplasias located in the small bowel and colon, and octreotide therapy seems to be more effective than lanreotide therapy. "
10.	IronIBA 12/01/2016 - "62 patients will be included with refractory anaemia due to small bowel angiodysplasias, who are RBC transfusion or iron infusion dependent despite endoscopic intervention and oral iron supplementation. " 04/30/2012 - "At the same time, bleeding from angiodysplasia in the coecum was masked by unauthorised perorally administrated iron. " 04/01/2009 - "Both patients were on oral iron therapy and the second one had a previous double-balloon enteroscopy, 2 years earlier, which revealed only ileal angiodysplasias. " 05/01/2011 - "intestinal angiodysplasia) may develop iron deficiency anemia refractory to oral iron supplementation. " 01/01/2023 - "We report the case of an 85-year-old male with severe aortic stenosis and recurrent small bowel angiodysplasias, requiring frequent blood transfusions and intravenous iron. "

Therapies and Procedures

1.	Therapeutics 09/01/2004 - "Based on the current concept of the obvious prevalence of surgical treatment of vascular angiodysplasias over low-invasive methods of interventional radiology, the author assesses the capacities of sclerotic therapy performed by the improved visual controlling procedure. " 09/01/2004 - "By using the well-known semiotics of ultrasound studies of angiodysplasias, the author has made significant methodological amendments to the techniques of sclerotic therapy. " 07/01/2023 - "At present, available treatments for angiodysplasia, including long-term VWF replacement therapy, are not very effective. " 10/01/2020 - "This therapy led to a substantial reduction of transfusion requirements and the improvement of angiodysplasias. " 01/01/2016 - "There are different types of therapies for angiodysplasia such as endoscopic, angiographic and pharmacological techniques. "
2.	Argon Plasma Coagulation 03/01/2012 - "The most frequently applied methods of endoscopic treatment of angiodysplasias, such as argon plasma coagulation, multipolar coagulation and heater probe, proved to be effective with certain shortcomings and the possibility of complications. " 01/01/2017 - "The primary aim of our study was to analyze lesion location, the efficacy of therapeutic endoscopy with argon plasma coagulation, and the factors associated with rebleeding in patients with gastrointestinal angiodysplasias. " 01/01/2003 - "Argon plasma coagulation is an effective treatment for gastric angiodysplasia in patients on dialysis." 06/01/2023 - "Upper endoscopy revealed perianastomotic angiodysplasias, treated by clipping and Argon-Plasma-Coagulation. " 01/01/2023 - "In the small intestine, argon plasma coagulation (APC) can be effectively used for the treatment of angiodysplasias. "
3.	Renal Dialysis (Hemodialysis) 10/01/2023 - "Also, the prevalence of Heyde's syndrome in populations who are predisposed to angiodysplasias, such as those on hemodialysis, is understudied. " 01/01/2005 - "We recently experienced a case of a female hemodialysis patient with multiple intestinal angiodysplasias. " 01/01/2003 - "We report three adult chronic hemodialysis patients with asymptomatic angiodysplasia. " 01/01/2003 - "Asymptomatic gastric angiodysplasia in chronic hemodialysis patients: case reports." 10/01/2016 - "Hemodialysis Switch Improved Colonic Angiodysplasia in a Peritoneal Dialysis Patient."
4.	Ligation 03/01/2012 - "Endoscopic ligation with elastic rings can be effective and safe for treatment especially of solitary gastric and duodenal angiodysplasias." 03/01/2012 - "The aim of the study was to examine the efficacy and safety of endoscopic treatment of gastric and duodenal angiodysplasias by ligation with elastic rings. " 03/01/2004 - "This study evaluated the treatment of gastroduodenal angiodysplasia by detachable mini-loop ligation. " 03/01/2012 - "There were no complications after ligation of angiodysplasias. " 03/01/2012 - "Patients were under follow-up after 2-3 days, 30 days and then every 6 months following the endoscopic ligation of angiodysplasias. "
5.	Electrocoagulation (Electrocautery) 12/01/1996 - "Electrocoagulation (bicap) of angiodysplasias was performed when accessible and not diffuse (<20). " 06/01/1987 - "While the larger cavernous angiomas necessarily call for surgery, large-bowel angiodysplasia and capillary angiomas, which are disease falling primarily within the internist's sphere of competence, may be treated conservatively, when symptomatic, by endoscopic electrocoagulation, though a surgical approach may be contemplated in that small percentage of cases presenting coagulopathy or frequent, intense haemorrhages with a severe anaemic tendency." 01/01/1987 - "Sixteen patients with gastrointestinal angiodysplasia requiring transfusion were treated with surgical resection, endoscopic electrocautery, or transfusion alone. " 01/01/1985 - "[Colonic angiodysplasia--its treatment by endoscopic electrocoagulation]." 10/30/1984 - "[Results of electrocoagulation of angiodysplasia of the colon]."