Jejunal Angiodysplasia in an Elderly Patient with Aortic Stenosis: Significance of Von Willebrand Factor as an Etiologic Factor.

Abstract

Heyde's syndrome is a disease in which patients with aortic stenosis (AS) bleed from angiodysplasia. An 80-year-old woman with a history of severe AS was referred to our hospital with melena and anemia. The patient underwent jejunal resection after repeated blood transfusions. A pathological examination revealed angiodysplasia, and the patient's plasma lacked high-molecular-weight von Willebrand factor (VWF) multimers, leading to the diagnosis of Heyde's syndrome. The patient underwent transcatheter aortic valve implantation (TAVI) one year after the diagnosis, and the VWF index recovered. This is a valuable case in which the pathological analysis of angiodysplasia associated with Heyde's syndrome was possible.

• Authors: Toshiyuki Kubo, Shinji Yoshii, Hiro-O Yamano, Masato Saito, Koichi Sakata, Shintaro Sugita, Tadashi Hasegawa, Hisanori Horiuchi, Hiroshi Nakase
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 62 Issue 14 Pg. 2059-2062 (Jul 15 2023) ISSN: 1349-7235 [Electronic] Japan
• PMID: 36418102 (Publication Type: Case Reports, Journal Article)

Chemical References

• von Willebrand Factor

Topics

• Female
• Humans
• Aged
• Aged, 80 and over
• von Willebrand Factor
• Gastrointestinal Hemorrhage (diagnosis)
• Aortic Valve Stenosis (complications, surgery)
• Transcatheter Aortic Valve Replacement (adverse effects)
• Colonic Diseases (complications)
• Angiodysplasia (complications, diagnosis)
• von Willebrand Diseases (complications, diagnosis)