Entamoebiasis

Infection with amoebae of the genus ENTAMOEBA. Infection with E. histolytica causes DYSENTERY, AMEBIC and LIVER ABSCESS, AMEBIC.

Also Known As:

Entamoeba Infections; Entamoeba histolytica Infection; Entamoeba Infection; Entamoeba histolytica Infections; Entamoebiases; Infection, Entamoeba; Infection, Entamoeba histolytica; Infections, Entamoeba; Infections, Entamoeba histolytica

Networked: 68 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Parasitic Diseases: 4870
  - Protozoan Infections: 282
    - Amebiasis: 1455
      - Entamoebiasis: 68

Related Diseases

1.	Liver Abscess
2.	Colitis
3.	Empyema
4.	Infections
5.	Amebic Dysentery (Amoebic Dysentery)

Experts

1.	Petri, William A: 3 articles (12/2014 - 02/2004)
2.	Ramos-Martínez, E: 3 articles (03/2004 - 07/2000)
3.	Talamás-Rohana, P: 3 articles (03/2004 - 07/2000)
4.	Brown, Gregory P: 2 articles (11/2019 - 01/2018)
5.	Shine, Richard: 2 articles (11/2019 - 01/2018)
6.	Šlapeta, Jan: 2 articles (11/2019 - 01/2018)
7.	Kobayashi, Seiki: 2 articles (01/2013 - 01/2010)
8.	Cheng, Xunjia: 2 articles (07/2012 - 11/2007)
9.	Tachibana, Hiroshi: 2 articles (07/2012 - 11/2007)
10.	Yang, Bin: 2 articles (07/2012 - 11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Entamoebiasis:

1.	LectinsIBA 04/26/2012 - "Efficacy of a Gal-lectin subunit vaccine against experimental Entamoeba histolytica infection and colitis in baboons (Papio sp.)." 01/01/2010 - "In a recent study in northern South Africa, the seroprevalence of Entamoeba histolytica infection among 257 HIV-positive and 117 HIV-negative individuals was determined, using an ELISA for the detection of antibodies reacting with the parasite's galactose/-acetyl-D-galactosamine(Gal/GalNAc)-inhibitable adherence lectin. "
2.	Metronidazole (Metric)FDA LinkGeneric 01/01/2010 - "A mass Entamoeba histolytica infection recurred despite repeated treatments with metronidazole at a rehabilitation institution for individuals with intellectual impairments. " 01/01/1972 - "Effect of metronidazole (Klion) on entamoeba histolytica infection of adults." 08/01/2021 - "Serological testing leads to Entamoeba histolytica infection, which was treated with metronidazole but no significant improvement on empyema and abscess liver size. " 11/01/1989 - "It appears that Flagyl and Fasigyn are not as efficacious as previously reported but are still much better than their generic counterparts for the treatment of symptomatic Entamoeba histolytica infections." 05/06/1978 - "Aboriginal children who were aged from six to nine years and living in Cherbourg Community were treated for Giardia Lamblia and Entamoeba histolytica infection with either the manufacturer's recommended dose of metronidazole (Flagyl) or with tinidazole (Fasigyn), at two-dose levels. "
3.	Subunit VaccinesIBA 04/26/2012 - "Efficacy of a Gal-lectin subunit vaccine against experimental Entamoeba histolytica infection and colitis in baboons (Papio sp.)."
4.	AntigensIBA 05/01/2008 - "The present study was conducted to compare two stool antigen detection kits with PCR for the diagnosis of Entamoeba histolytica infections by using fecal specimens submitted to the Department of Microbiology at St. Vincent's Hospital, Sydney, and the Institute of Medical and Veterinary Science, Adelaide, Australia. " 11/01/1999 - "Recent studies suggest that stool antigen assays are more sensitive and specific than microscopy for the diagnosis of Entamoeba histolytica infection. " 03/01/2007 - "Importance of the detection of amoebic antigens in stool samples for the diagnosis of Entamoeba histolytica infection, among children in southern Turkey." 12/01/2004 - "Comparison of PCR and antigen detection methods for diagnosis of Entamoeba histolytica infection." 10/01/1995 - "Rapid diagnosis of Entamoeba infection by using Entamoeba and Entamoeba histolytica stool antigen detection kits."
5.	Leptin ReceptorsIBA 12/16/2014 - "Leptin receptor mutation results in defective neutrophil recruitment to the colon during Entamoeba histolytica infection." 03/01/2011 - "A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children." 05/01/2011 - "Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. " 10/01/2011 - "New genetic studies indicate that polymorphisms in apolipoprotein E or the leptin receptor modulate children's risk for diarrhea and Entamoeba histolytica infection, respectively, thereby linking two genes important for lipid metabolism to enteric infections. "
6.	Galactose (Galactopyranose)FDA LinkGeneric 01/01/1993 - "Diagnosis of pathogenic Entamoeba histolytica infection using a stool ELISA based on monoclonal antibodies to the galactose-specific adhesin." 11/01/1993 - "Differentiation of pathogenic Entamoeba histolytica infections from nonpathogenic infections by detection of galactose-inhibitable adherence protein antigen in sera and feces." 01/01/2010 - "In a recent study in northern South Africa, the seroprevalence of Entamoeba histolytica infection among 257 HIV-positive and 117 HIV-negative individuals was determined, using an ELISA for the detection of antibodies reacting with the parasite's galactose/-acetyl-D-galactosamine(Gal/GalNAc)-inhibitable adherence lectin. "
7.	AntibodiesIBA 01/01/1991 - "Protective immunity to entamoeba histolytica infection in subjects with antiamoebic antibodies residing in a hyperendemic zone." 01/01/1984 - "Sera from 15 patients with Entamoeba histolytica infection were tested for anti T-cell antibodies by assessing cross-reacting specificities with the antigens defined by an anti-Ia hybridoma antibody. " 01/01/2010 - "In a recent study in northern South Africa, the seroprevalence of Entamoeba histolytica infection among 257 HIV-positive and 117 HIV-negative individuals was determined, using an ELISA for the detection of antibodies reacting with the parasite's galactose/-acetyl-D-galactosamine(Gal/GalNAc)-inhibitable adherence lectin. "
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/01/1992 - "Modulation of tumor necrosis factor production by macrophages in Entamoeba histolytica infection." 09/01/2003 - "We used Entamoeba histolytica infection in human intestinal xenografts to study the roles interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of amebic colitis. "
9.	Interleukin-18 (Interleukin 18)IBA 06/01/2003 - "In the present study, the cytokines interleukin (IL)-12 and IL-18 were evaluated for their capacity to modulate and to re-direct in vitro parasite antigen-specific cellular responsiveness in patients exposed to Onchocerca volvulus and Entamoeba histolytica infection. "
10.	CytokinesIBA 06/01/2003 - "In the present study, the cytokines interleukin (IL)-12 and IL-18 were evaluated for their capacity to modulate and to re-direct in vitro parasite antigen-specific cellular responsiveness in patients exposed to Onchocerca volvulus and Entamoeba histolytica infection. "

Therapies and Procedures

1.	Therapeutics 06/01/1989 - "Current therapy of Entamoeba histolytica infection requires use of multiple agents effective at different body sites, including the intestinal lumen, intestinal tissue, and liver. " 01/01/2014 - "The same applies to protozoa; in this chapter, Babesia species, free-living amoebae and Entamoeba histolytica infection, including severe meningitis and brain abscess, infection by Trypanosoma species (South American and African trypanosomiasis) are discussed with respect to history, epidemiology, clinical signs, and symptoms as well as differential diagnosis and therapy. " 05/26/2021 - "We urge clinicians to consider Entamoeba histolytica infection if severe colitis progresses after steroid therapy. " 01/08/2023 - "Herein, we report a representative case of a ten-month-old male patient with severe acute malnutrition (SAM) admitted to the Emergency Paediatric Clinic in Port Sudan for amoebic dysentery complicated by hypovolemic shock and sepsis, treated by target therapy for Entamoeba histolytica infection associated with empiric antibiotic therapy. "
2.	Canes (Cane) 11/01/2019 - "In 2014, an outbreak of entamoebiasis associated with a novel species of Entamoeba induced clinical illness and poor body condition in free-ranging cane toads in Australia's Northern Territory. " 11/01/2019 - "Pathology Associated With an Outbreak of Entamoebiasis in Wild Cane Toads (Rhinella marina) in Tropical Australia." 01/01/2018 - "Invasive Colonic Entamoebiasis in Wild Cane Toads, Australia."
3.	Splenectomy 09/01/1985 - "The effect of splenectomy on resistance of mice to Entamoeba histolytica infection."
4.	Intramuscular Injections 08/01/1994 - "We successfully treated a serious case of Entamoeba histolytica infection showing brain abscess, meningitis, and liver abscess by oral administration of metronidazole, intramuscular injection of dehydroemetine, and drainage of the brain abscess. "
5.	Drug Therapy (Chemotherapy) 10/01/2023 - "We report a case of fulminant amoebic colitis resulting from an asymptomatic Entamoeba histolytica infection, which was activated by chemotherapy for gastric cancer. "