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Azetidines

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Azetines
    - Azetidines: 8

Experts

1.	Comer, Eamon: 4 articles (05/2024 - 01/2020)
2.	Melillo, Bruno: 4 articles (05/2024 - 01/2020)
3.	Schreiber, Stuart L: 4 articles (05/2024 - 01/2020)
4.	Sharma, Amit: 4 articles (05/2024 - 01/2020)
5.	Borrel, Julien: 3 articles (05/2024 - 01/2020)
6.	Chatterjee, Arnab K: 2 articles (05/2024 - 02/2024)
7.	Ence, Chloe C: 2 articles (05/2024 - 02/2024)
8.	Mittal, Payal: 2 articles (05/2024 - 02/2024)
9.	Sibley, L David: 2 articles (05/2024 - 02/2024)
10.	Uddin, Taher: 2 articles (05/2024 - 02/2024)

Related Diseases

1.	Infections 05/14/2024 - "Previous studies have shown that bicyclic azetidines are potent and selective inhibitors of apicomplexan phenylalanine tRNA synthetase (PheRS), leading to parasite growth inhibition in vitro and in vivo, including in models of Toxoplasma infection. " 02/28/2024 - "Previous studies have shown that bicyclic azetidines are potent and selective inhibitors of apicomplexan phenylalanine tRNA synthetase (PheRS), leading to parasite growth inhibition in vitro and in vivo, including in models of Toxoplasma infection. "
2.	Neuralgia (Stump Neuralgia) 08/01/2010 - "A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca(V)3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. "
3.	Malaria 12/01/2021 - "The inhibition of Plasmodium cytosolic phenylalanine tRNA-synthetase (cFRS) by a novel series of bicyclic azetidines has shown the potential to prevent malaria transmission, provide prophylaxis, and offer single-dose cure in animal models of malaria. " 12/01/2021 - "Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines."
4.	Human Influenza (Influenza) 05/15/2006 - "Azetidines 5 and 6 were both markedly active against influenza A H2N2 virus, 10- to 20-fold more potent than amantadine. "
5.	Type 2 Diabetes Mellitus (MODY) 11/01/2005 - "Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. "

Related Drugs and Biologics

1.	Phenylalanine (L-Phenylalanine)
2.	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)
3.	T-Type Calcium Channels (T-Type Calcium Channel)
4.	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)
5.	Pyrrolidines
6.	Amides
7.	Amantadine (Aman)