ERRalpha Estrogen-Related Receptor

11/01/2008 - "Although stable knockdown of ERRalpha expression in MDA-MB-231 cells had no effect on in vitro cell proliferation, a significant reduction of tumor growth rate was observed when these cells were implanted as xenografts. "
01/01/2015 - "Estrogen-related receptor alpha (ERRα) is one of the members of the NR superfamily and studies have linked it with a wide variety of cancers. "
10/20/2023 - "Estrogen-related receptor alpha (ERRα) is a central regulator of cellular energy metabolism associated with poor cancer prognosis. "
05/01/2022 - "Estrogen-related receptor alpha in select host functions and cancer: new frontiers."
01/01/2019 - "Estrogen-related-receptor alpha (ERRα) has been implicated in cancer cell invasiveness. "

11/01/2023 - "Estrogen-Related Receptor Alpha (ERRα) Promotes Cancer Stem Cell-Like Characteristics in Breast Cancer."
01/01/2023 - "Metabolic switching of estrogen-related receptor alpha in breast cancer aggression."
01/01/2019 - "Previously, we demonstrated that inhibition of estrogen-related receptor alpha (ERRα) significantly disrupts mitochondrial metabolism and that this results in substantial antitumor activity in animal models of breast cancer. "
03/15/2016 - "Increasing evidences suggested that the expression of estrogen-related receptor alpha (ERRα) was correlate with unfavorable clinical outcomes of breast cancer patients. "
03/15/2016 - "Estrogen-related receptor alpha (ERRα) signaling has recently been implicated in breast cancer. "

07/01/2007 - "ERRalpha(-/-) mice subjected to left ventricular (LV) pressure overload developed signatures of heart failure including chamber dilatation and reduced LV fractional shortening. "
02/01/2009 - "Overall, our results implicate PGC-1alpha and ERRalpha in the pathophysiology of human heart failure, and define dynamic target gene sets sharing known interrelated regulatory mechanisms capable of contributing to the mitochondrial dysfunction characteristic of this disease process."
07/01/2007 - "These results demonstrate that the nuclear receptor ERRalpha is required for the adaptive bioenergetic response to hemodynamic stressors known to cause heart failure."
07/01/2007 - "We hypothesized that the estrogen-related receptor alpha (ERRalpha), which recruits PGC-1alpha to metabolic target genes in heart, exerts protective effects in the context of stressors known to cause heart failure. "

05/01/2006 - "This study was to explore the regulatory effect of 17beta-estradiol (17beta-E(2)) on ERRalpha expression, and to elucidate the relationship between ERRalpha and ER signal pathway in endometrial carcinoma cell lines. "
01/01/2006 - "To discuss the role of ERRalpha in the endometrial carcinoma cells, this study was performed. "
02/16/2023 - "Estrogen-related receptor alpha (ERRα) plays an important role in endometrial cancer (EC) progression. "
01/01/2018 - "Estrogen related receptor alpha triggers the migration and invasion of endometrial cancer cells via up regulation of TGFB1."
08/01/2009 - "It is speculated that ERRalpha is a candidate for prognostic factors in uterine endometrial cancer, although ERRs are not directly related to growth of uterine endometrial cancer."

01/01/2019 - "In this study, we found that estrogen-related receptor alpha (ERRα, also called NR3B1) binds to OTUB1 promoter and regulates its expression in colorectal cancer. "
07/01/2005 - "These findings suggest that ERRalpha, as well as the two ERs, might play a critical role in the progression of the colorectal cancer."
10/05/2022 - "Previous studies have shown that Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Beta (PGC-1β) and Estrogen-Related Receptor Alpha (ERRα) are over-expressed in colorectal cancer and promote tumor survival. "