Thyroid Hormone-Binding Proteins

Membrane-bound proteins found in the ENDOPLASMIC RETICULUM of CULTURED CELLS and NEOPLASMS. They were identified originally based on their capacity to bind THYROID HORMONE.

Also Known As:

3,5,3'-triiodothyronine-Binding Protein; Cytosolic Thyroid Hormone-Binding Protein; Pyruvate Kinase Muscle Isozyme; Pyruvate Kinase, M1 Isozyme; T3-Binding Protein p55; T4-Binding Protein p55; Thyroid Hormone-Binding Protein; Thyroid Hormone-Binding Protein p55; Thyroid Hormone-Binding Protein p58; Triiodothyronine-Binding Protein p55

Networked: 51 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Thyroid Hormone-Binding Proteins: 51
  - Membrane Proteins: 10078
    - Thyroid Hormone-Binding Proteins: 51

Experts

1.	Dang, Guohui: 2 articles (01/2022 - 11/2019)
2.	Feng, Juan: 2 articles (01/2022 - 11/2019)
3.	Han, Lulu: 2 articles (01/2022 - 11/2019)
4.	Ma, Xiaolong: 2 articles (01/2022 - 11/2019)
5.	Miao, Yutong: 2 articles (01/2022 - 11/2019)
6.	Wang, Xian: 2 articles (01/2022 - 11/2019)
7.	Yang, Juan: 2 articles (01/2022 - 11/2019)
8.	Bonnet, Sébastien: 1 article (04/2022)
9.	Boucherat, Olivier: 1 article (04/2022)
10.	Breuils-Bonnet, Sandra: 1 article (04/2022)

Related Diseases

1.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2023 - "This study aims to explore the effects of microRNA-1286 (miR-1286) on the development of non-small cell lung cancer (NSCLC) via the aerobic glycolysis pathway by targeting pyruvate kinase muscle isozyme M2 (PKM2). "
2.	Neoplasms (Cancer) 01/07/2014 - "JMJD5 interacts directly with pyruvate kinase muscle isozyme (PKM)2 to modulate metabolic flux in cancer cells. " 01/01/2021 - "As a rate-limiting enzyme of glycolysis, pyruvate kinase muscle isozyme M2 (PKM2) participates in tumor metabolism and growth. " 03/01/2016 - "Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. " 06/01/2016 - "PKM2, GFPT1, and G6PD affect the pathologic complete response rate of neoadjuvant chemotherapy patients in different ways; pyruvate kinase muscle isozyme 2 (PKM2) and G6PD are closely associated with the molecular subtypes, whereas GFPT1 is correlated with cancer size. " 09/18/2014 - "We discuss the rationale for developing such drugs and review three targets with central roles in metabolic pathways crucial for cancer cell growth: pyruvate kinase muscle isozyme splice variant 2 (PKM2) in glycolysis, glutaminase in glutaminolysis, and mutations in isocitrate dehydrogenase 1 and 2 isozymes (IDH1/2) in the tricarboxylic acid cycle. "
3.	Hyperthyroidism 01/01/1983 - "Serum T4 is a good test for hyperthyroidism in patients with normal thyroid hormone-binding protein levels. " 07/01/1981 - "There was no significant change in thyroid hormone binding protein concentrations in 10 subjects who remained hyperthyroid. " 07/01/1981 - "Concentration of serum thyroid hormone binding proteins after 131I treatment of hyperthyroidism." 12/20/1980 - "The estimation is thus indicated in all patients with changes in thyroid hormone binding protein concentration and is of great value in confirming or ruling out the diagnosis of T3-toxicosis, T4-toxicosis and in all cases of "preclinical" or borderline hyperthyroidism." 10/01/1982 - "A negative correlation between serum thyroid hormone binding protein (TBG and TBPA) and free thyroxine was observed in patients with hyperthyroidism. "
4.	Familial Dysalbuminemic Hyperthyroxinemia 10/01/1994 - "Results of thyroid hormone-binding protein tests confirmed the diagnosis of familial dysalbuminemic hyperthyroxinemia. " 03/01/1989 - "The validity of FT4 results has been questioned mainly in euthyroid patients with altered concentrations of thyroid hormone-binding proteins, as in nonthyroidal illness, hereditary analbuminemia, familial dysalbuminemic hyperthyroxinemia (FDH), and the presence of iodothyronine-binding antibodies. " 12/01/1988 - "To determine whether thyroid hormone-binding proteins in serum, particularly albumin, facilitate the transfer of T4 into human tissues, we studied cellular T4 uptake (CT4) by human liver (Hep G2) cells from medium containing serum from subjects with familial dysalbuminemic hyperthyroxinemia (FDH) and acquired and familial T4-binding globulin (TBG) excess and patients with normal T4-binding to albumin and normal TBG concentrations. "
5.	Hypothyroidism 11/21/1987 - "Experimental data are discussed which support the proposal that antagonist binding of PCBs to thyroid hormone binding proteins in serum could produce varying degrees of hypothyroidism. " 01/01/1987 - "We concluded that: the abnormalities in thyroid function tests in patients on long-term dialysis (HD and CAPD) do not express the existence of a true hypothyroidism; a different pathogenesis of the low-T4 syndrome in the CAPD and HD groups may be hypothesized: in the former it could be attributed to a reduction in serum-binding capacity for thyroid hormones, in the latter the relative increase in fT4 percentage despite normal TBG levels suggests either the presence of T4-TBG-binding inhibitor(s), or structural abnormalities of thyroid-hormone-binding proteins." 12/01/2007 - "Endocrine disorders including hypothalamus dysfunction, hypopituitarism, syndrome of inappropriate anti-diuretic hormone secretion, diabetes insipidus, growth hormone disorders, hyperprolactinemia, gonadotropin deficiency, serum thyroid hormone-binding protein abnormalities, hypothyroidism, hyperthyroidism, hypomagnesium, hypocalcemia, hyperparathyroidism, hyperparathyroidism, adrenal dysfunction, gonadal dysfunction, hypertriglyceridemia, hypercholesterolemia, diabetes mellitus, and glycosuria were identified and their association with cancer therapies were outlined. "

Related Drugs and Biologics

1.	Thyroid Hormones
2.	Thyroxine (Levothyroxine)
3.	Proteins (Proteins, Gene)
4.	Prealbumin (Transthyretin)
5.	Enzymes
6.	Antibodies
7.	Facilitative Glucose Transport Proteins (Glucose Transporter)
8.	Pyruvate Kinase
9.	Hormones (Hormone)
10.	Hexokinase

Related Therapies and Procedures

1.	Neoadjuvant Therapy
2.	Therapeutics
3.	Continuous Ambulatory Peritoneal Dialysis (CAPD)