Concentration of serum thyroid hormone binding proteins after 131I treatment of hyperthyroidism.

Abstract

Serum concentrations of the thyroid hormone binding proteins, thyroxine binding globulin, prealbumin, and albumin were determined in 30 thyrotoxic patients before and after 131I treatment. Each patient was placed into one of three groups according to response to treatment. The serum concentration of all three proteins rose significantly in 10 patients who became euthyroid, and a greater increase was seen in 10 patients who developed hypothyroidism. There was no significant change in thyroid hormone binding protein concentrations in 10 subjects who remained hyperthyroid. Changes in the concentration of thyroid hormone binding proteins should be borne in mind when total thyroid hormone concentrations are used to monitor the progress of patients receiving treatment for hyperthyroidism.

• Authors: J S Harrop, M R Hopton, J H Lazarus
• Journal: Annals of clinical biochemistry (Ann Clin Biochem) Vol. 18 Issue Pt 4 Pg. 211-4 (Jul 1981) ISSN: 0004-5632 [Print] England
• PMID: 6269478 (Publication Type: Journal Article)

Chemical References

• Iodine Radioisotopes
• Receptors, Cell Surface
• Receptors, Thyroid Hormone
• Thyroxine-Binding Proteins
• Triiodothyronine
• Thyrotropin
• Thyroxine

Topics

• Humans
• Hyperthyroidism (blood, drug therapy)
• Hypothyroidism (chemically induced, metabolism)
• Iodine Radioisotopes (therapeutic use)
• Receptors, Cell Surface (metabolism)
• Receptors, Thyroid Hormone
• Thyrotropin (blood)
• Thyroxine (blood)
• Thyroxine-Binding Proteins (metabolism)
• Triiodothyronine (blood)