Secreted Aspartic Proteases

Enzymes that are produced and secreted by organisms, including bacterial and fungi.They are involved in a variety of biological processes, such as nutrient acquisition, pathogenesis of candida, and host tissue invasion.

Also Known As:

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Monod, Michel: 2 articles (06/2013 - 07/2002)
2.	Aoki, Wataru: 1 article (01/2016)
3.	Bochenska, Oliwia: 1 article (01/2016)
4.	Gogol, Mariusz: 1 article (01/2016)
5.	Klaga, Kinga: 1 article (01/2016)
6.	Kozik, Andrzej: 1 article (01/2016)
7.	Ostrowska, Dominika: 1 article (01/2016)
8.	Rapala-Kozik, Maria: 1 article (01/2016)
9.	Ueda, Mitsuyoshi: 1 article (01/2016)
10.	Wolak, Natalia: 1 article (01/2016)

Related Diseases

1.	Oral Candidiasis (Thrush) 01/01/1998 - "[Investigations on the regulation of secreted aspartyl proteases in a model of oral candidiasis in vivo]." 06/01/2001 - "The aim of this study was to explore anti-Candida albicans systemic and mucosal humoral responses against Candida virulence antigens such as somatic antigen and secreted aspartic proteases (Saps) in HIV-infected patients with oral candidiasis. "
2.	Infections 01/01/2023 - "Secreted aspartyl proteases (SAPs) are important enzymes for fungal pathogenicity, playing a significant role in infection and survival. " 06/01/2013 - "Such infection starts with the penetration of the organism at the mucosal surfaces, facilitated by the secreted aspartic proteases (Saps) 4, 5, and 6. The functional mechanism of these virulence factors is unclear. " 01/01/2011 - "Some virulence factors, like the secreted aspartic proteases (Saps), play a role in several infection stages and the inhibition of one of the many stages may contribute to the containment of the pathogen and thus should help in the treatment of disease. " 10/30/2015 - "albicans during infection such as secreted aspartyl proteases (Saps) and shed mucin Msb2 can reduce Hst 5 activity; and human salivary mucins, while suggested to protect Hst 5 from proteolytic degradation, can entrap peptides into mucin gels, thereby reducing bioavailability. "
3.	Mycoses (Diseases, Fungus) 01/01/2016 - "Candida albicans, a causative agent of opportunistic fungal infections in immunocompromised patients, uses ten secreted aspartic proteases (SAPs) to deregulate the homeostasis of the host organism on many levels. " 08/14/2015 - "Aspartic proteases are a class of enzymes that play a causative role in numerous diseases such as malaria (plasmepsins), Alzheimer's disease (β-secretase), fungal infections (secreted aspartic proteases), and hypertension (renin). "
4.	Candidiasis (Moniliasis) 01/01/2023 - "Expanding the therapeutic options for Candida infections using novel inhibitors of secreted aspartyl proteases." 07/01/2002 - "Pathogenesis of the various forms of candidiasis was shown to be associated with the differential and temporal regulation of the expression of genes coding for secreted aspartic proteases (Sap). "
5.	Malaria 08/14/2015 - "Aspartic proteases are a class of enzymes that play a causative role in numerous diseases such as malaria (plasmepsins), Alzheimer's disease (β-secretase), fungal infections (secreted aspartic proteases), and hypertension (renin). "

Related Drugs and Biologics

1.	Antigens
2.	Virulence Factors (Pathogenicity Factors)
3.	Enzymes
4.	Amyloid Precursor Protein Secretases (beta-Secretase)
5.	Renin
6.	Peptides (Polypeptides)
7.	Peptide Hydrolases (Proteases)
8.	Mucins
9.	Gels